維生素a前體脂質(zhì)體的制備及微膠囊性質(zhì)研究

1、重慶大學(xué)碩士學(xué)位論文維生素A前體脂質(zhì)體的制備及微膠囊性質(zhì)研究姓名：劉巧蓮申請學(xué)位級別：碩士專業(yè)：生物物理學(xué)指導(dǎo)教師：葉志義20090605重慶大學(xué)碩士學(xué)位論文英文摘要ABSTRACTIIlrecentyears，VitaIIlinA(vitaIIlinA，VA)hasbeenwidelyusedinfbod，cosmetics觚dmedicinesHoweverVAisvulnerabletosomeenviroIlrnentalcon

2、ditionssuchaLslight，oxygen，wllichc鋤accelera_teitsde伊adation，觚dli嘶titSapplicationhltllisstudyVAproliposomeswerepreparedbyoilinwater(O廠W)andgelsiccationt0enhancethestabilityofVA鋤dmakeitmoreconV即i鋤tinst01age鋤dapplications，I

3、IlttlispaperWestudiedprep娥ltiontecllIlology，physicaJ鯽dche嘶calnatureaIlds詘ilityoftheVAproliposomes，鋤d觚dcomparedthephysicalnatll托ofitwiththatofR0cheVAIIlicroencapsulesWedete丌Ilinatedthemoisture，thebulkdenstitythesolubility

4、，thec∞sum姐gle，thesizedistribution觚dotherphysicalpropertiesofrnicrocapsuleproductscalculateditspayloadTheresultsshow酣：themostconVeni即tmoistu咒contentforproliposoInesstorageis242％；bulkdensityis057g，cm’；solubilityis897％；zero

5、鋤gleis37o，thenowablilityis900d；thepayloadis1400％TheaverageofIIlicrocapsulessizeis205033岬Wechosesoybeanlecithinastherawmaterims，preparedtheVAliposomesbyO，Wmethodshlordert0impr0Vethestabilityoft11eliposomes，wepreparedVApro

6、liposomesbygelsiccationmethodW|eoptiInizedtheprescriptionbyonhogonaLldesigII，usingtheenc印sulationemciency勰鋤indeX，鋤dgotthebestprescriptionforliposomespreparation：thephospholipidconcentrationat4％，the船廿oofVA鋤dphospholipidsi

7、sl：40，cholesterolaIldphospholipid’sratiois1：8WedidsoInepharmac即ticalphaHnacyeVmuation0nproliposomes，thenlol訕olo舀caJch姐gesofVAliposomesbeforeanda肚rgelsiccationw勰considerThcresultsshowed：thepaIticlesizewere424499衄beforcgel

8、siccation觚d4305l20nma舭rthedistributionoffreeze一嘶酣VAliposomesstrag舀eslightlya艇rgelsiccationEncapsulationra_tesbefbreaIlda缸rgelsiccationwere831％鋤d798％Thestal)ilityinVestigationshowedmatgelsiccationliposomesprocesshasnosign

9、ific柚tinfluenceo印roliposomeappe袱mceAfertgelsicca石0nproliposomespHincreaSedslightly’觚averagepaniclesizeinc咒ascdslightlyaIldtheenc印sulationef!ficiencydecre雒edsli曲tlyPhysical鋤dchernjcalpfopertiesofproliposomeshavebeeninVest