抗仔豬腹瀉中藥口服液的制備及質量標準研究.pdf

1、東北農(nóng)業(yè)大學碩士學位論文抗仔豬腹瀉中藥口服液的制備及質量標準研究姓名：孟倩申請學位級別：碩士專業(yè)：基礎獸醫(yī)學指導教師：李繼昌20070620StudyonthePreparationandQualityStandardofThetraditionalChinesemedicineoralLiquidAgainstPost—weaningSwineDiarrheaAbstractPostweaningswinediarrheaisacom

2、monprobleminpigfarms，seriouslyinfluencingpiggrowth，evencausingtodie，caminggreatdamagetopigraisingindustryisoneofthemostimportantfactorsthatrestricttheeconomydevelopmentofpigraisingindustryInthisstudyaccordingtotheChinese

3、veterinarymedicinetheoriesandtheetiopathogenisis，cardinalsymptomandt11epathopeiesismechanism，twelveChinesetraditionalmedicinesRadixPulsatillae，RhizomaCoptidis，CortaPhellodendri，RadixScutellariae，RadixAs加agaBRaidixPaeonia

4、eAlbaRadixAngelicaeSinensis。RadixAucklandiaeRh垃Ⅲ4AtractylodisMacrocephalae，PoHaFructmCrataegi，RadixGlycytthizaeworechoosedtodothebacteriostasisexperimentinvitroTheusedstralaswereEcoli07s，EcoliO2la，EeoliOz，hogcholeramlmon

5、ella。TheantibacterialactivitiesoftheChinesetraditionalmedicinesagainstfourstrainsweretestedbydoublingdilutionmethodinvitro，andtheMICswereme∞uredThenfiveChinesetraditionalmedicineswhichhadbetterantibacterialactivitieswere

6、choosedtopreparethreedifferentcompounds，andalsotheMICsofthecompoundpreparationweremeesuredFinallythebestcompoundwasconsfitudedbyRh括omaCoptidisRadixSeutellariaeRadixGlyeytthizae，RadixAucklancliaeFructusMume1n恤aspcctofprep

7、aringtechnologytheoralliquidwasselectedunitedwithpathogenyclinicalod，doseetc11“extractingmethodswereselectedaccordingtotheeffectivecmponentspharmacologicalactjoILphysicalandchemicalpropertyetcRhizomaCoptidiswereextracted

8、byalcohol，theoptimumextractionconditionwasinvestigatedwithorthogonaldesignmethodbydeterminingthecontentofberberineRadixScutellariaewasdecoctedbywatertheoptimumpreparingcraftwasgainedbyorthogonaltesttakingthecontentofbaic

9、alinasstudyindexes：RadixGlycytthizaeRadixAucklandiaeandFructusMumeweredecoetedbywatertheoptimumpreparingcraftwasgainedbyorthogonaltesttakingthecontentofGlycyrrhizinasstudyindexes；Theresultsshowedthattheoralliquidpreparat

10、iontechnologywas：Rh拓omaCoptidisWereextractedby70％alcohol，extracting2times，every15hours，adding12timesamountofthe70％aleoh01RadixScut￡llariaewasdecoetedby16timesamountofwaterextracting2timesevery15hoursneOthersweredecoctedb