TIMP-1對人牙周膜細胞增殖及其ALP活性表達的影響.pdf

1、山西醫(yī)科大學碩士學位論文TIMP1對人牙周膜細胞增殖及其ALP活性表達的影響姓名：高曉林申請學位級別：碩士專業(yè)：口腔臨床醫(yī)學指導教師：李瑛20100315山西醫(yī)科大學碩士學位論文Abstractlobjectivel：1’llisseriesofe沖eriments豳edatevaluat姆hebiologicale虢ctsoftissueiIlllib“orofmetalloproteiIlase一1(TIMP一1)ontheprol

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4、1ng枷、10119／面、50llg／IIll、100Ilg／m1)ofTIM1Tlliazolyblue(MTT)coloriInet血assayandALPactivityaIlalysiswere璐edatdi腦renttilllepo缸s(the24th，48thand72thhours)t0detenI]IiIletheproliferationandALPactivityofHPDLCafterdifferemdosesof

5、TIMP1wereadded硫otheculturemedium【Resunl：(1)ceUproli向ation：Whencomparedwithcomrolgroup，1n鮒【IllTIMP一1at24t11，48th鋤d72thho峨l0ng／mlTIMP—lat48th鋤d72thho峨morcs適Ilificantlypro】motedtheproliferationofHPDLC(2)ALPactiVity：1ng／IIll

6、TIMP一1at24t11，48th鋤d72thho塢10ng／lIllTIMP一1at48thhourmores垃Ilificantly硫re嬲edtheALPactivityofHPDLC1Conclusion】：Thisstudyh嬲indicatedthat1rIMP1maysmltaneouslypromotethepr0Hferationanddi臟remiationofhuInanperiodontal岵鋤entcensT

7、IlisconcIusion砌icatI甜thatTIMP1h嬲up—regulatione能ct南rHPDLCproli佬ratioll111isstudyII町proVideaeXperimemalb鵲is旬rnewattacllnlemaIldremodelofperiodontiumaf【erperiodomitistreatInentKeywords：humanperi0(10ntalKg鋤entceUs，Tissueintl