（R）-N-（3-氟-4-嗎啉苯基）-噁唑酮-5-甲基醇合成新工藝研究.pdf

1、～782225授予單位代碼：!Q4塑研究生學(xué)號：——密級：——鄭州大學(xué)碩士學(xué)位論文(工程碩士)論文題目：(盟二叢=(3二氬==里啦苤基2二豎唑倒二5二里基醒一一盒鏖蘊王苧班塞研究生姓名：黃強學(xué)科門類；王堂專業(yè)領(lǐng)域：絲堂王捏導(dǎo)師、職稱：一趔國匝!教授2005年4月16日——一塑型奎蘭堡主蘭篁笙莖AbstractThenewsynthetictechnologyof(R)一N(3一Fluoro一4一morpholinylphenyl)一2o

2、xo一5一oxazolidinylmethanolwasstudied3Fluoro一4一morpholinylnitmbenzeneWaspreparedby34一difluoronitrobenzeneandmorpholine3Fluom4一morpholinyl—nitrobenzenereactedwithFeinwatertoafford3Fluoro一4一morpholinylanilineThentheinteracti

3、onof3Fluoro4一morpholinylanilineandphosgenegave3Fluoro4morpholinylphenuyl—isocyanateFinallythereactionof3Fluoro4morpholiny1phenuyl—isocyanatewith(R)glycidyIbutyrategaveanewproductwhich懈catalyzedbysodiummethoxideandreacted

4、withmethanoltosynthesize(R)N一(3Fluoro4一morpholinylphenyl)一2oxo5oxazolidinylmethan01CatalystswereappliedasNa2C03andFe，whichcouldbeobtainedeasilyandcheap，insteadofdiisoproprlethylamineandPd／CPhosgeneastherawmaterialWasused

5、insteadofbenzylchlomformateThenewmethodhadmanyadvantagessuchasthesimpleoperationsteps，thelowpricematerialsandtheloweringproductioncostUsingmorpholineand34difluoro—nitrobenzeneforthesynthesisof3fluoro4morpholinly—nitroben

6、zeneWestudythee船ctsofrawmaterialratio，reactiontemperatureandreactiontimeontheproductionyieldstheoptimumsynthesisconditionsweren(3，4一difluoronitrobenzene)：n(morpholine)：n(sodiumcarbonate)一1：14：0052，reactiontemperature78℃，

7、andreactiontime6htheproductionyieldswereover98％thepuritywasover995％fm01)Thecomplexw勰characterizedbyUVVis，IR，1HNMRandelementalanalysisTheoptimumconditionsfor3Fluoro4一morpholinylanilineweren(3一fluoro4morpholinlynitrobenzen

8、e)：n(Fe)=1：452reactioninwatertemperature96“C，andreactiontime5htheproductionyieldswereover90％Determinationsolubilityof3Huomorpholinylanilineinwateracetone，ethylacetate，tetrachloromethane，trichloromethane，DMFethanol，benzen