mba論文蒙特利爾認知評估量表在烏魯木齊pdf

1、新疆醫(yī)科大學(xué)碩士學(xué)位論文蒙特利爾認知評估量表在烏魯木齊姓名：那祖克.玉素甫申請學(xué)位級別：碩士專業(yè)：神經(jīng)病學(xué)指導(dǎo)教師：朱沂2011-04新疆醫(yī)科大學(xué)碩士學(xué)位論文 新疆醫(yī)科大學(xué)碩士學(xué)位論文 2A Preliminary Study of Application of Montreal Cognitive Assessment Among The Uyghur people in Urumqi Postgraduate: Nazuk.yu

2、sup Supervisor: Prof. Zhu Yi Abstract Objective : To develop a Uyghur version of the Montreal Cognitive Assessment （MoCA-U）, to evaluate it’s reliability and validity Among The Uyghur people in Urumqi, and to determi

3、ne the optimal cutoff score of MoCA-U that to detect the cognitive impairment in Uyghur people. Methods: translated the English MoCA and adapted it into Uyghur version. The MoCA-U, MMSE, CDR and other neuropsychological

4、 batteries were administered to 188 Uyghur people（normal controls=80, MCI=68, dementia=40） who were randomly selected and aged 50～75. Results: MoCA-U had good internal consistency, Cronbach’sαwas 0. 801, inter-rater reli

5、ability ICC= 0.977（95%CI：0.949—0.990）, Test?retest reliability were high（r=0.987，P < 0.001）,The MoCA-U scores were strongly correlated with those of MMSE and CDR. MoCA-U scores were significantly different in the 3 gr

6、oups( P < 0.001 ). In the participants with 5 years of education or less Using a cutoff score of 20, the MoCA-U had a sensitivity of 86.4 % and a specificity of 84.2 % for screening MCI. Using a cutoff score of 13,

7、the MoCA-U had a sensitivity of 94.1% and a specificity of 100% to detect dementia. In the participants within 6～10 years of education, Using a cutoff score of 21, the MoCA-U had a sensitivity of 84.6 % and a specificity

8、 of 94.1% for screening MCI. Using a cutoff score of 15, the MoCA-U had a sensitivity of 100 % and a specificity of 92.3% to detect dementia. In the participants with more than 11 years of education, Using a cutoff score

9、 of 22, the MoCA-U had a sensitivity of 75.8 % and a specificity of 70.5% for screening MCI. Using a cutoff score of 17, the MoCA-U had a sensitivity of 100 % and a specificity of 84.8% to detect dementia. Conclusion: Th

10、e MoCA-U had a good reliability , validity and feasibility, suitable for use as a screening tool to screen cognitive function in elderly Uyghur people in Urumqi. The optimal cutoff score for different education years to