N-正丁基苯并異噻唑酮的合成研究.pdf

1、浙江大學(xué)碩士學(xué)位論文N正丁基苯并異噻唑酮的合成研究姓名：王凌申請學(xué)位級別：碩士專業(yè)：應(yīng)用化學(xué)指導(dǎo)教師：胡望明20060501浙江大學(xué)磷士學(xué)位論文ABS薯RACTTransdermaIdeliverysystemisakindofdrugdeliverysystemthatdrugs，whichpenetratetheskinsabsorbedbycapillaryvesseIenterintothebodycirculationandb

2、ringIntocurativeeffect1nordertoovercometheskinbarrierpenetrationenhancersareoftenusedtoincreasetheblooddrugconcentrationsothattheskinpenetrationvelocityandconcentrationofthedrugscanreachthecurativedemandTherefore，thedeve

3、lopmentandapplicationofpenetrationenhancerbecomeextremelyimportantThisthesisjsaboutthesynthesisofanewpenetrationenhancerofgreatefficiency：thiazoneOrthogonaltestmethodwasusedforstudyingonthesynthesisofthiazoneunderphasetr

4、ansfercatalysiscondition，usingsodiumsaccharinand1butyIbromideasreactantstetrabutvIammOniumbromide(TBAB)asphasetransfercatalyst。Themainfac幻rsandtheminortactorswerediscussedthroughtheexperimentsTheexperimentaIresultsindica

5、tedthattherea&iontemperatureandthedosageof1_butylbromidewerethemainfactorswhilethereactiontimeandthedosageofTBABweretheminorfactorsTheincreaseofreactiontemperatureanddosageof1butylbromidecouldbothincreasetheyieldofproduc

6、tincertainscopebuttheexcessincreasingofthemmightbringinmuchbyproductsExtendingthereactiontimecouldnotremarkablyincreasetheyieldofproductWhenthemolarratioofTBABand1出utyIbromidewasabove005：thelncreaseofT8ABdosagecouldhardl

7、yincreasetheyieldTheoptimizedparameterswerethatthefeedingofsodiumsaccharinand1由utyIbromidewasonthetheoryratioat100℃for10hundertheconditionthatthemolarratioofTBABand1一butylbromidewas005：1Thustheyieldwas8763％withwhitedrysh

8、eetcrystalobtainedAnewsynthesistechniqueofthiazonewasdevelopedThefeedingofsodiumsaccharinand1butyIbromidewasonthetheoryratiointhesolventofOMFwithoutanyphasetransfercatalystTheexperimentalresultslndicatedthattheyieldofpro

9、ductincreasedatfirstbutdecreasedafterwardswhenincreasingthereactiontemperaturefoftheexcesslncreasingoftemperaturebroughtinthebyproductsjncreaseThemostappropriatetemperaturewas100℃ThemeltingpointdeterminationthelRspectrum

10、analysisandtheelementanalysisofthiazonewerecarriedoutTheresultsmatchtheIiteraturevaluesandthetheoryvaluesBesidesthese，theside。reactionandtheseparationofimpuritywerediscussedinthethesissupportingthefurtherresearchinthefut