基于機器人機構(gòu)學(xué)的F0F1ATP合成酶馬達能量儲存研究.pdf

1、西南交通大學(xué)碩士學(xué)位論文基于機器人機構(gòu)學(xué)的F0F1ATP合成酶馬達能量儲存研究姓名：武江勇申請學(xué)位級別：碩士專業(yè)：機械設(shè)計及理論指導(dǎo)教師：李立201106西南交通大學(xué)碩士研究生學(xué)位論文第1I頁AbstractBionano—robotisoneofthescientificresearchfrontiersnowadaysThemolecularmotoraspowersectionplaysa11importantroleinbion

2、anorobotTheFoFIATPsynthasemotorasoneofmolecularmotorwidelyandnaturallyexistsinsidethelivingcreatmesWhenADPandPisynthesizeintoATPmolecules，theFoFIATPsynthasefirstlytransformselectricpotentialenergyintomechanicalenergy，the

3、ntransformsmechanicalenergyintochemicalenergyandstoragesitintotheKRmolecules；andwhenATPmoleculesdiscomposeintoADPandPitheenergywillbetransformedintheoppositewayFoFlATPsynthasemotorhasdrawnmoreandmoreattentionofresearcher

4、sandbecomeahotspotinbio—nanorobotresearchbecauseitsenergytransformationefficiencycanapproximatelyreachto100％FoFIATPsynthaseisaspecialkindofproteinwhichiscomposedbypolypeptidechainsofaminoacidconnectedbypeptidebondsBasedo

5、nthefactthat，thepolypeptidechainissimilartoahyperredundantrobotwhoselinkagesareconnectedwithrevolutepairsthekeyissueoftheenergystorageinFoFIATPsynthasemoterhasbeenstudiedfromtheenergychangeofhydrogenbondbyapplyingtherobo

6、ticmechanismtheoryforthefirsttimeinthisthesisasfollowsFirstly，byapplyingthetheoryofroboticmechanisms，theroboticmechanismmodelofproteinpolypeptidechainconsideringpeptidebondtwistisestablished，basedonthepropertiesoftheprot

7、einpolypeptidechainandtheatoms’positionsSecondly，the0c—helix、13sheetandfltumwhicharethemostcommonintheproteinsecondarystructme，aresimulatedbyutilizingtheabovementionedmodeloftheproteinpolypeptidechainAndthesimulationresu

8、ltsshowthat，thespaceconformationofproteinsecondarystructurecanbeaccuratelymanifestedbythismodelandthenthevalidityofthemodelisprovedThirdly，asimpleandquickmethodforcalculatinghydrogenbondingelectrostaticisproposedbasedont