癥狀性動(dòng)脈粥樣硬化性顱內(nèi)動(dòng)脈狹窄的影像學(xué)特征與內(nèi)科治療效果的相關(guān)性分析.pdf

1、分類號：R743密級：公開UDC：610學(xué)校代碼：11065碩士專業(yè)學(xué)位論文癥狀性動(dòng)脈粥樣硬化性顱內(nèi)動(dòng)脈狹窄的癥狀性動(dòng)脈粥樣硬化性顱內(nèi)動(dòng)脈狹窄的影像學(xué)特征與內(nèi)科治療影像學(xué)特征與內(nèi)科治療效果的相關(guān)性分析效果的相關(guān)性分析劉建茂指導(dǎo)教師滕繼軍副教授學(xué)位類別臨床醫(yī)學(xué)碩士專業(yè)領(lǐng)域神經(jīng)病學(xué)答辯日期2017年5月20日ⅡCrelationbetweenimagingfeaturesofsymptomaticatheroscleroticintracr

2、anialarterialstenosistheeffectofmedicaltreatmentAbstractObjective:toevaluatethepredictivevalueofimagingfeaturesinthetreatmentofpatientswithsICAS.Methods:InJanuary20152016inJuneweed136patientswithsymptomaticintracranialvu

3、larstenosisinourhospitalallofwhomwereadmittedtothehospitalfthefirsttimewithacutecerebralinfarction，Therewere75males61femaleswithanaverageageof58.578.32years.AccdingtotheNationalInstitutesofHealthStrokeScale(NIHSS)sceafte

4、rtheonsetof6h1thepatientsweredividedinto29groups:progressivestrokegroupnonprogressiongroup(n=107).Theclinicaldatalabatytestsimagingdatawerecollectedthedifferencesbetweenthetwogroupswerecompared.Thecrelationbetweentheimag

5、ingfeaturesofsICASpatientstheirmedicaltreatmentwereanalyzedbylogisticregressionanalysis.Results136casesofpatientswithsymptomaticintracranialarterystenosisinprogressiongroup29cases107casesofnonprogressiongroupUnivariatean

6、alysisshowedthatglycatedalbuminlevelsinprogressiongroup(P=0.016)lowdensitylipoproteincholesterol(P=0.032)homocysteine(P=0.047)cerebralmicrobleeds(P=0.038)theproptionofintracranialvularstenosis(severedegreeofresponsibilit

7、yocclusion)ratio(P=0.010)wassignificantlyhigherthanthatinnonprogressiongroup.Multivariatelogisticregressionanalysisshowedthatglycatedalbumin(=1.21495%CI:1.0711.376P=0.002)theresponsibilityofvularstenosis(=3.04495%CI:1.12

8、78.227P=0.023)wereindependentpredictsofpotreatmenteffectofsICASConclusion:Theimagingfeaturesofsymptomaticintracranialvularstenosisisrelatedtotheeffectofmedicaltreatmentsevereintracranialarterialstenosisocclusionglycateda