色胺酮、吳茱萸次堿等天然產(chǎn)物的生物合成及仿生合成研究.pdf

1、西北大學(xué)博士學(xué)位論文色胺酮、吳茱萸次堿等天然產(chǎn)物的生物合成及仿生合成研究姓名：王翠玲申請(qǐng)學(xué)位級(jí)別：博士專業(yè)：中藥學(xué)指導(dǎo)教師：劉建利20070501要!!奎竺堡主蘭堡絲蘭莖苧墊莖AbstractStudyonthebiosynthesisandbiomimeticsynthesisofnaturalproductsoftryptanthrin，rutaecarpineetcThekeystepofanewdrugresearchandde

2、velopmentisgettingthebioactivecompoundswithacceptablepriceExtractionandisolationisoneimportantmethodtogetthebioactivecompounds，butusuallyexpensiveIfthepropersyntheticmethodc姐bedevelopedthemanufacturecostofbioactivecompou

3、ndswillbereducedalotThiskindofbioactivecompoundswillbedevelopedtonewdrugpossiblyInthisdissertationthebiomimeticstrategywasusedtosynthsizethe仃yptaIlthJill，mtaeearpIne，13b，14hydrorutaeearpineevodiamineluotuoninAandtheirder

4、ivatives，inordertocarfyoutthenewdrugsresearchanddevelopmentTryptanthrinanditsfourderivativesweresynthesizedfromisatinoritsderivativesandanthranilicacidiIIthepresenceofPOCl3intolueneandTHFaccordingtothebiosyntheticrouteTr

5、yptanthrinwasalsosynthesizedbycatalyzedcondensationofisatinandisatoicanhydridethroughaconvenientonestepsynthesisin80％yieldTheconditionsemptoyedinthepresentsynthesisaremild，efficientandgeneralTryptanthrinhasbeenresearched

6、anddevelopedasthecandidateofnewdrugRutaecarpineevodiamineand13b，14dihydromtaecarpinehavebeensynthesizedbythetrifluoroaceticanhydridemethodAnovelandpracticalsyntheticmethodofmtaecarpinewasdesignedwhichwasstartingfromacryl

7、onitrileanddiethylmalonatcviaMichaeladditionreactionJappKlingemannreactionFischerreactionandcondensationwith56％overallyiela’Anovelandefficientmethodwasappliedtosynthesisluotonin氣whichinvolvesthetwocomponentscondensationo

8、f3oxo一1Hpyrrolo[3^6】quinolineandisatoicanhydrideunderalkaliconditionsTheimportantintermediate3oxo‘1Hpyrrolo[3，46】quinolinewaspreparedbytheFriadlandercondensationof2aminobenzaldehydeand2oxobutyrieacid，nucleophilieaddition