白藜蘆醇關(guān)鍵中間體（E）-3，5-二甲氧基-4′-乙酰氧基二苯乙烯的合成研究和天然產(chǎn)物spongistatin 1：CD-螺環(huán)縮酮前體—δ-內(nèi)酯的合成研究.pdf

1、西北師范大學(xué)碩士學(xué)位論文白藜蘆醇關(guān)鍵中間體（E）3，5二甲氧基4′乙酰氧基二苯乙烯的合成研究和天然產(chǎn)物spongistatin1：CD螺環(huán)縮酮前體—δ內(nèi)酯的合成研究姓名：吳江林申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：有機(jī)合成指導(dǎo)教師：胡雨來(lái)20070501@；萬(wàn)業(yè)Af缸史謦碩士生論文吳江林酮前體6一內(nèi)酯：不對(duì)稱Reformastsky反應(yīng)AbstractThethesismainlyconsistsofthefollowingthreechapters

2、ChapterOne：theBlologlcalActivltyandthePreparationofResvertrol(review)InthissectionabriefintroductionofthedevelopmentofresvertroIincludingthebiologicalactivityandthepreparationindetailwasgivenChaptertwo：theSynthesisof3，5d

3、imethoxyl4acetoxyldistilbeneThechapterincludedtwosectionsInsectionone，3。5dimethanesurlfonoxylbenzaldehydewassynthesizedfrombenzoicacidin40％overallyieldbysulfonation、alkalifusion、acidification、esterification、protection、re

4、duction、oxidationThereactionconditionofsulfonationwasdiscussedInsectiontwo，Thereactionof4一acetoxylbenzylbromideand3，5dimeth—oxylbenzaldehydetogive(日3，5一dimethoxyl一4’‘a(chǎn)cetoxyl—distilbenewasinvestigatedThereactionobtained3

5、0％overallyieldThereactionconditionwasoptimizedChapterthree：Syntheticstudiesofspongistat|n1：AconvergentapproachtosynthesisofCD—Spiroketal6lactoneInthischapter，Thesynthesisof5lactone，whichwillbeusedinsynthesisofCD—Spiroket

6、alinspongistatin16lactonewasinvestigatedusing(R)一malicacidasstartingmaterialTheasymmetryReformatskyreactionof2((s)2，2dimethyl一1，3dioxolan一4一yl一)acetaldehydeandethyl3hydroxy一4一((s)2，2dimethyl1，3dioxolan4yl一)butanoatewasdi