Ⅰ Abnormality of CTCF transgenic mice in glucose homeostasis;Ⅱ Role of c-fos and associated MAPK pathways in stresses induced c.pdf

1、Pancreatic islet endocrine cells play crucial roles in regulation of glucose homeostssis.The differentiation and function of islet are cells are regulated by various transcription transcription factors,including Pax6,ame

2、mber of the homeobox gene family.To further investigate the effect of ctcf on regulating Pax6 function in pancreatic islet cells,we measured blood giucose, insulin and glucagons levels in newly established transgenic mic

3、e overexpressing CTCF.With comparision of wildtype mice.CTCF trangenic mice demonstrate an increase in insulin level and decrease in glucagon level resulting in lower blood glucose levels.In insulin tolerance test,hypogl

4、ycemtia occure quickiy in CTCF transgenic mice and lakes a recovery time.In the mean time,glucagon levels in CTCF mulant mice were significantlly lower compared to its wildtype counterpart.To further investigate the effe

5、ct of ctcf on regulating Pax6 function in pancreatic islet cells,we measured blood giucose, insulin and glucagons levels in newly established transgenic mice overexpressing CTCF. Oue results indicate that CTCF TRANSGENIC