大腸癌組織中細胞周期蛋白cyclinD1、cyclinE的表達規(guī)律初探.pdf

1、同濟醫(yī)科大學(xué)碩士學(xué)位論文大腸癌組織中細胞周期蛋白cyclinD1、cyclinE的表達規(guī)律初探姓名：石軍申請學(xué)位級別：碩士專業(yè)：普通外科指導(dǎo)教師：楊傳永2000.5.1J研qr醫(yī)科大掌97颯碩士牛業(yè)論文AbstractRecentmedicalstudiesbasedOilmolecularbiologyindicatesthattherelationbetweencellcycleandcarcinogenesisisnotasepa

2、rateevent，cancerisakindofdiseaseabnormalitiesincellcycle。Gl／Scheckpointisimportantforcellcycletransitionbecauseitdecidestheinitiationoftheeellcycle。AsthemainregulativefactorsinGlphase，Glcyclins，iecyclinDl、cyclinEplayalli

3、mportantroleincarcinogenesis。Inpresentstudy，multiparameterflowcytometryisemployedtodetecttheexpressionofthecyclinDtandcydinEinfleshhumancolorectalsample。Result：Comparedwithnormalcells，tumorcellshavehigherproliferationind

4、ices(P005)：cyclinDloverexpressionoccurredin6006(13／22)ofcolorectalcanced，andcyclinE，64％(14／22)；inmetastasisgroup，82％tumorhavehighlevelofcyclinDlexpressionbutitsoverexpressionhadnOsigmgicantrelationwithmetastasis；andcydin

5、E，91％(10／H)。theabnormalexpressionofcyclinEhadsignigicantrelationwithmetastasis；therelationbetweenthecyclinsabnormalexpressionandinvasiondepthoftumorWasnotsignigicantConclusion：(1)inhumancolorectaltumor，overexpressionofcy

6、clinDlandcyclinEpromotecellthroughGl／ScheckpointtOenterSphraseSOtheyplayanimportantroleincarcinogenesis(2)abnormalexpressionofcyclinDIandcyclinEmighttakepminandpromotetheprogressionofcolorectaltumoranditmightheusedasaacc