多烯磷脂酰膽堿注射液的毛細管氣相色譜分析.pdf

1、河北大學碩士學位論文多烯磷脂酰膽堿注射液的毛細管氣相色譜分析姓名：趙玉申請學位級別：碩士專業(yè)：藥物分析學指導教師：楊更亮20080601AbstractAbstractStatisticsshowthatthereareabout120millionhepatitisBviruscarriersand30millionchronichepatitisBpatientsinChinaAtpresent，polyenephosphatidy

2、lcholineinjectionwhichcanbeappliedtomanykindsofliverdiseaseisarlaffirmativeliveraidincurativeeffectItismainlyusedintheacuteorchronichepatitis，thelivercirrhosisaswellastheliversurgery’StreatmentandSOonCurremlyChinesePharm

3、acopoeiahasnotgatheredthequalitystandardofthismedicineInordertoguaranteethesafetyandeffectivenessofthemedicine，andconnecttointernationaltrail，itisnecessarytoconducttheresearchonthequalitycontrolofpolyenephosphatidylcholi

4、neinjectionBeingahighefficientseparationandanalysistechnologywithfastspeed，highsensitivity，smallsampleamountused，accurateandreliableresults，capillarygaschromatography(CGC)ismoreandmoreextensivelyappliedinpharmaceuticalan

5、alysisInthispaperthecapillarygaschromatographyisappliedtoconductthequalitycontrolresearchonbenzylalcoholinthepolyenephosphatidylcholineinjectionandresidualsolventsinthecrudedrugTherearethreechaptersinthisthesisChapterone

6、：Areviewmainlyconcernedwiththegoalandthesignificanceofthedrugsqualitycontrol，theformulationprincipleandprimarycoverageofdrugsqualitystandard，confirmationoftheanalysismethodofchemistrymedicinequalitycontrolandtheresearcha

7、boutpolyenephosphatidylcholineChaptertwo：BenzylalcoholisanotherimportantingredientinthepolyenephosphatidylcholineinjectionbesidestheprincipalconstituentpolyenephosphatidylcholineIndentificationtestofbenzylalcoholwascarri

8、edoutAtthesametime，contentdeterminationandstabilitytestsofbenzylalcoholweredonebytheCGCTheresultsofconfirmationtotheanalysisindicatedthattheCGCwasrapidandconvenientMoreovertheaccuracyishigh，thereproducibilityisgoodandthe

9、resultisreliableAlltheseindicatedtheCGCcallbeusedincontrollingthequalityofbenzylalcohol。Chapterthree：BecauseethylalcoholandacetoneareusedintheproductionprocessofpolyenephosphatidylcholinecrudedrugsandtheICHlistethylalcoh