CD133在白血病及骨髓增生異常綜合征中的表達及與CD34和預后因素的相關性研究.pdf

1、青島大學碩士學位論文CD133在白血病及骨髓增生異常綜合征中的表達及與CD34和預后因素的相關性研究姓名：趙會霞申請學位級別：碩士專業(yè)：血液內(nèi)科指導教師：王偉20050523青島大學碩士學位論文TheExpressionofCDl33inLeukemiaandMyelodyspIasticSyndromeAnditsRelationshipwithCD34andPrognosticFactorsAbstractobjectiveToev

2、aluatetheexpressionofCDl33anditsclinicalsignificanceinleukemiaandmyelodysplasticsyndrome(MDS)patientsandtoexploreitsrelationshipswiththeexpressionofCD34andprognosticfactorsMethodsTheexpressionofCDl33andCD34in29casesofacu

3、temyelocyticleukemia([AML)，14casesofacutelymphoblasticleukemia(ALL)，9casesofchronicleukemiaand9casesofMDSstudiedbyusingimmunocytochemistryResults①ThepositiveratesofCDl33inAML，ALL，chronicleukemiaandMDSpatientswere552％，429

4、％，222％and556％respectively@TheexpressionofCDl33inAMLpatientswassignificantlyhigherthanthatincontrolgroup(P001)However，therewerenosignificantlydifferencesinCDl33expressionbetweenALLandnormalcontrol，neitherwereMDSnorchronic

5、leukemia⑤InallthepatientstheexpressionofCDl33vcassignificantlycorrelatedwitlltheexpressionofCD34(P001)，especiallyobviousinAMLpatiems(PO01)InALLpatientstheexpressionofCDl33wasalsocorrelatedwiththeexpressionofCD34(P005)④Th

6、eexpressionofCDl33hadnorelationshipwiththeclinicalprognosticfactorssuchaSthepercentagofleukemiccellinperipheralbloodandinbonemarrow，WBCcounts，hemoglobincouncentrationplateletcounts，sexageandLDHlevel⑤TheexpressionofCDl33w

7、erehighlypositivein2AMLpatientstransformedfromMDSTherewerenoexpressionofCDl33inchronicneutrophilicleukemia(CNL)andchroniclymphocyticleukemia(eLL)patientsConclusionsAMLhadsignificantlyhigherCDl33expressioncomparedwithnorm