1 以取代烯酮為底物的不對稱環(huán)丙烷化反應研究;2 Indolactam-V類似物的合成研究.pdf

1、復旦大學博士學位論文1以取代烯酮為底物的不對稱環(huán)丙烷化反應研究2IndolactamV類似物的合成研究姓名：蔣詠文申請學位級別：博士專業(yè)：有機化學指導教師：馬大為2002.5.1AbstractYongwenJiang(OrganicChemistry)Supervisor：ProfDaweiMaAsweknow，compoundsthatareabletoselectivelymodulatetheindividualPKCisozy

2、mesorsubtypesofmetabotropicglutamatereceptors(mGluRs)carlserveasvaluableresearchtoolsintheelucidationoftheirphysiologicalrolesAdditionally，suchcompoundsholdpromiseinthedevelopmentofnoveltherapeuticsforthetreatmentofhuman

3、diseases，suchascancerandAlzheimer’SdementiaL—Glutamateisthemajorexcitatoryaminoacidneurotransmitterinthecentralnervoussystemandoperatesthrou曲multipleiontropicandGproteincoupledreceptorsToseekfurtherthestructureactivity、r

4、elationshipofconformationallyconstrainedanaloguesofglutamicacid，allkindsofgeneralandefficientsyntheticmethodsarehighlydesiredInthefirstpartofthethesis，inconnectionwithoureffortsonthestudiesofselectivemodulatorsofmetabotr

5、opicglutamatereceptors，wedevelopedamethodofstereoselectivecyclopropanationofsulfoniumylideswithenonesBasedonthisreaction，wehavesucceededinsynthesizingsomebiologicallyimportant12，3一trisubstitutedcyclopropanes(conformation

6、allyconstrainedglutamicacidanalogues)suchasCCGanaloguesMeanwhile，wedrawinspirationfromthisreactionofcyclopropanationanddevelopedasyntheticmethodofenantiopuretetrasubstituteddihydrofuranThesecondpartisaboutthestudyofthesy

7、nthesisoftheanaloguesofIndolactamVWetriedtoprocessthissyntheticrouteviatheCu—catalyzedcouplingreactionofarylhalidesanda—aminoacids，butwefoundindolecompoundsarenotavailablesubstancetothisreactionWealsostudiedtheFriedel—Cr

8、aftsacylationofL—Tryptophan’SderivativesandusedL—TryptophanasastartingmaterialtosynthesizesomeanaloguesofILVAtlast，basedonthestructureofILV，wedesignedandsynthesizedtwelve—memberedringindolactamKeywords：stereoselectivecyc