芫花瑞香烷型二萜原酸酯類化合物對DNA拓撲異構酶Ⅰ的抑制作用與構效關系研究.pdf

1、大連理工大學碩士學位論文芫花瑞香烷型二萜原酸酯類化合物對DNA拓撲異構酶Ⅰ的抑制作用與構效關系研究姓名：李曉娜申請學位級別：碩士專業(yè)：應用化學指導教師：張世軒20060601芫花瑞香烷型二萜原酸酯類化合物對DNA拓撲異構酶I的抑偉0作用及構效關系研究TheInhibito巧ActiVityandQSARofDaphneDite印eneEsterstowardsDNATopoisomeraseI仔Om_D諺p矗胛P船，后wdAbstrac

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6、mhesizedandcharacterizedThefeasibilityofMichealadditionreactionforyuanhuacineaIldglutathionewasattempted，accordingly，“wasdeducedtIlatdapllIlediterpeneestefscallnotreactedWimsulfydrylcompoundsuchas91utamione，itisalsoillum

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8、exllibitedpotemiIlhibitoryactiVitiesagainsttopoIatIC50IeVelsof111～534州TheQSARstudyindicatedthatmeonhoestergroupindaphnediterpeneesterwasnecessaryfortheirlhibitoryactivityagainsttopoI，electrondonatinggmupscan洫cre嬲emeiIlMb

9、itoryactivity，aJldelectron—w“h出awinggroupsdecreasetlleiIlllib“oryactivityInsummary，dapllIlediteIperleestersareanewtypeofDNAtopoIirlllib“orsbearingdifbrentstmctllrescompared謝也theknowntopoIiI血ib王torsc鋤ptothecinallditsanalo