芫花瑞香烷型二萜原酸酯類化合物對(duì)DNA拓?fù)洚悩?gòu)酶Ⅰ的抑制作用與構(gòu)效關(guān)系研究.pdf

1、大連理工大學(xué)碩士學(xué)位論文芫花瑞香烷型二萜原酸酯類化合物對(duì)DNA拓?fù)洚悩?gòu)酶Ⅰ的抑制作用與構(gòu)效關(guān)系研究姓名：李曉娜申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：應(yīng)用化學(xué)指導(dǎo)教師：張世軒20060601芫花瑞香烷型二萜原酸酯類化合物對(duì)DNA拓?fù)洚悩?gòu)酶I的抑偉0作用及構(gòu)效關(guān)系研究TheInhibito巧ActiVityandQSARofDaphneDite印eneEsterstowardsDNATopoisomeraseI仔Om_D諺p矗胛P船，后wdAbstrac

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5、nc，yualllluadine，”anhuaginea11dyuanhu叩ine，鋤ongtllem，”mhuagineobtained矗omJDgenkwaformefirsttimeTheirstmctureswereelucidatedbyacombinationofUV，IR，MSaIldNMRspectraInordertoexploretheQSAR，threederivativesofyuallhuacineweresy

6、mhesizedandcharacterizedThefeasibilityofMichealadditionreactionforyuanhuacineaIldglutathionewasattempted，accordingly，“wasdeducedtIlatdapllIlediterpeneestefscallnotreactedWimsulfydrylcompoundsuchas91utamione，itisalsoillum

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8、exllibitedpotemiIlhibitoryactiVitiesagainsttopoIatIC50IeVelsof111～534州TheQSARstudyindicatedthatmeonhoestergroupindaphnediterpeneesterwasnecessaryfortheirlhibitoryactivityagainsttopoI，electrondonatinggmupscan洫cre嬲emeiIlMb

9、itoryactivity，aJldelectron—w“h出awinggroupsdecreasetlleiIlllib“oryactivityInsummary，dapllIlediteIperleestersareanewtypeofDNAtopoIirlllib“orsbearingdifbrentstmctllrescompared謝也theknowntopoIiI血ib王torsc鋤ptothecinallditsanalo