線粒體DNA T1095C突變分子流行病學(xué)調(diào)查及MIT聾病分子機(jī)制的研究.pdf

1、溫州醫(yī)學(xué)院碩士學(xué)位論文線粒體DNAT1095C突變分子流行病學(xué)調(diào)查及MIT聾病分子機(jī)制的研究姓名：王金丹申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：遺傳學(xué)指導(dǎo)教師：管敏鑫呂建新20070501溫州醫(yī)學(xué)院碩士學(xué)位論文中英文縮略詞對(duì)照表英文縮寫(xiě)英文名稱中文名稱AABRAlaAmAnA：rPase6CColC02C03CytobGGlvIlemtDNANDlND2ND3ND4ND5adenine腺嘌呤核苷auditorybrainstemresponsealan

2、ineamino#ycosideantibioticsATPsynthaseFOsubunit6cytosmeCytocIlromecoxidasesubunit1Cytocllromecoxidasesubunit2Cytocllromecoxidasesubunit3CytocbromebguanineglycineisoleucinemitochonddalDNANADHdehydrogenasesubunit1NADHdehyd

3、rogenasesubunit2NADHdehydrogenasesubunit3NADHdehydrogenasesubunit4NADHdehydrogenasesubunit5聽(tīng)覺(jué)腦干反應(yīng)丙氨酸氨基糖甙類抗生素ATP合成酶FO亞單位6胞嘧啶核苷細(xì)胞色素C氧化酶亞單位1細(xì)胞色素c氧化酶亞單位2細(xì)胞色素C氧化酶亞單位3細(xì)胞色素b鳥(niǎo)嘌呤核苷甘氨酸異亮氨酸線粒體DNA還原型煙酰胺腺嘌呤二核甘酸脫氫酶亞單位l還原型煙酰胺腺嘌呤二核甘酸脫氫酶

4、亞單位2還原型煙酰胺腺嘌呤二核甘酸脫氫酶亞單位3還原型煙酰胺腺嘌呤二核甘酸脫氫酶皿單位4還原型煙酰胺腺嘌呤二核甘酸脫氫酶亞單位5NSHLnomsyndromichearingloss非綜合征型聽(tīng)力損失OXPHOSoxidativephosphorylation氧化磷酸化PCRpolymedsechainreaction聚合酶鏈?zhǔn)椒磻?yīng)PTApuretoneaudiometry純音測(cè)聽(tīng)Ser(UCN)tRNAserine攜帶絲氨酸的tRNA

5、Sers嘶ne絲氨酸Tthymine胸腺嘌呤核苷111rthreonine蘇氨酸Valvaline纈氨酸LHONLeberHereditaryOpticNeuropathyLeber遺傳性視神經(jīng)病MMMitochondrialMyopathy線粒體肌病ADAlzeimer’SDisease阿爾采默氏病PDP刪nsom’SDisease帕金森氏病NARPNeurogenicmuscleweakness，Ataxia神經(jīng)源性的肌肉無(wú)力，共濟(jì)