β-cat,cyclin D-,1-和c-myc表達與胰腺癌發(fā)生及生物學行為關(guān)系的研究.pdf

1、青島大學碩士學位論文βcatcyclinD和cmyc表達與胰腺癌發(fā)生及生物學行為關(guān)系的研究姓名：歷建強申請學位級別：碩士專業(yè)：病理學與病理生理學指導(dǎo)教師：紀祥瑞李玉軍2002.4.1英文摘要EXPRESSl0N0Fp—cat，cyclinDlANDCmycANDTHE0CCURANCEANDBIoLOGICBE—HAVl0R0FPANCREATICCANCERABSTRACTObjectiveTostudytherelationship

2、betweentheabnormalexpressionofffcatenin(0eat)andthehighexpressionofcyclinD1andcmycandtheoecurance，proliferation，infiltration，metastasisandprognosisofpancreaticcancerandtoproviderationalefortheclinicaldiagnosisandtreatmen

3、tMethodsImmunohistochemicalPicTure7”wasusedtOtesttheexpressionofeat，cyclinD1andcmycin47casesofthecanceroustissueofthepancreas，12casesofthepancreaticintraepithelialneoplasiaand10casesofnormaltissueofthepancreas，respec—tiv

4、elyPancreaticcancerproliferationnuclearantigen(PCNA)wasalsotestedasthein—dexoftheextentofproliferationOfthepancreaticcancerResults8catwasexpressednormallyinthe10casesofthenormalpancreatictis—sue，whilecyclinDlandcmycweren

5、egativeTheexpressionratesofcat，cyclinDIandcmycinthetissuesofthepancreaticintraepithelialneoplasiaandthepancreaticcancerhadnosignificantdifference(500％and681％50O％and745％417“and702％，respectively；礦一0689，0213，PO05；P=1000)The

6、abnormalex。pressionrateofOestwassignificantlycorrelatedtOthemetastasisofthepancreaticcanearandoneyearsurvivalrate(#=6230，5495，PO05)TheexpressionrateofcyclinDlwascorrelatedwiththeproliferationofthepancreaticcancerandtheex

7、tentofdifferentiation(F一6187，P005)Theexpressionrateofomycwasnotcorrelaledwiththesize，theextentofpro。liferation，infihration，metastasisoroneyearsurxivalrate(P=10000208F一0002一l_347，PO05)，butcloselywiththeproliferationactivi