30502.多取代環(huán)丙烷開(kāi)環(huán)反應(yīng)的研究

1、揚(yáng)趔態(tài)堂亟堂僮論塞目錄中文摘要1Abstract：!第一章前言4122與三鍵的[32】環(huán)加成7123【33】環(huán)加成反應(yīng)8124其他反應(yīng)：91241其他環(huán)加成反應(yīng)91242DA環(huán)丙烷參與的入名反應(yīng)～101243其他反應(yīng)11第三節(jié)多取代環(huán)丙烷在天然產(chǎn)物全合成中的應(yīng)用12參考文獻(xiàn)。15第二章多取代環(huán)丙烷為底物的GewNd反應(yīng)(一)18211儀器與試劑19212實(shí)驗(yàn)步驟20213實(shí)驗(yàn)結(jié)果一20第二節(jié)實(shí)驗(yàn)結(jié)果討論互28第三節(jié)本章小結(jié)29參考文獻(xiàn)3

2、0第三章多取代環(huán)丙烷參與的Gewald反應(yīng)(二)31311儀器與試劑一31312實(shí)驗(yàn)步驟3l31212一苯甲?；?芳基1乙氧甲?；?氰基環(huán)丙烷的反應(yīng)3131232芳甲酰基3一芳基一l，1二氰基環(huán)丙烷的反應(yīng)36第二節(jié)實(shí)驗(yàn)結(jié)果討論41第三節(jié)本章小結(jié)一42參考文獻(xiàn)43第四章多取代環(huán)丙烷的二聚反應(yīng)44411儀器與設(shè)備46412實(shí)驗(yàn)步驟46413實(shí)驗(yàn)結(jié)果一46414一步合成方法52第二節(jié)實(shí)驗(yàn)結(jié)果討論一53第三節(jié)本章小結(jié)54參考文獻(xiàn)55揚(yáng)州大學(xué)學(xué)位

3、論文原創(chuàng)性聲明和版權(quán)使用授權(quán)書(shū)57蘭揚(yáng)趔太堂亟堂僮途塞CollegeofChemis哪andChemica】Engi驛e血嗡YallgzllouUniVersity，YangZllou，ChiI】=aThesisforMasterDe伊eeCycliadditionReactionsofpolysubstitutedcyclopropanesAuthor：Wan—quanTangt。j0M匈or：Ph鋤aceuticalengineer

4、ingTutor：Pro￡ⅥngHallDate：OCt2013AbstractCyclopropalleshaVefounda淅derallgeof印plicationsinmodemorg；micsynthesisAJldithasdra、ⅣnsigIlific鋤ta_ttemionsofmechemistsoverthepaStdecadeIntroductionofvadous劬ctionalgroupsintothecyclo

5、propaneringextendsitsreactivit)rsignificantlyTheyreactwitllbothnucleophilesa11delec仃opllilesHoweVer，themostinterestings)，11thetic印plicationofDon0卜Acceptorcyclopropanesisrelatedtot：heirabilit)，toreact，underLe、^，isacidoror

6、gaIlicbasesmediatedconditionstoaHbrdfiveorsixmemberedcarboaIldheterocvclesHere，weprocessaseriesofexperimentsofpolysu_bst“utedcyclopropanesmediatedbyo曙痂cbasesunde瑪oingaV撕et)rofreactionsAndwe’veacllievedaseriesofmealling如1

7、experimentalresults1W色useaseriesofcyclopropalles(2(4Nitrophenyl)3a巧l—cyclopmpane1，1dicarbonitrileand1Cyano一2(4nitrophenyl)一3一aryJ—cyclopropanecarboxylicacidethylester)toactasreactalltsinaGewaldReacti冊(cè)Undertheconditjongiv

8、eninthereferences，the陀actionsuccess如1lyyieldedfourteen2一Amino5(4nitrophenyl)4一phenylthiophene3carbonitrjlederiVatiVesWeScreenedreactionconditionstoselecttheoptimalreactionconditionsThereactionresultshavebeencharacterized

9、byNMR，IR，HItMS鋤dXRav2Weuseas甜esofcyClopropanes(2BellzoyJ一3aryl一cyclopmpane1，1dicarbonitmea11d1一Cyano2benzoyl一3一arylcyclopropallecarboxylicacidethylester)toactasreactaJltsinaGewaldReactionUndertheconditiongivenintllerefer