45572.tα1在原核細(xì)胞中的融合表達(dá)及活性研究

1、學(xué)校代碼：』!!至業(yè)分類號(hào)：籩Y888225研究生學(xué)號(hào)：密級(jí)：東牡括予葒大謄碩士學(xué)位論文1246203079九Toc1在原核細(xì)胞中的融合表達(dá)及活性研究FusionExpressionandactivity1陀stingofThymosinⅡlinprokaryoticces作者：耿迎俊指導(dǎo)教師：學(xué)科專業(yè)：研究方向：學(xué)位類犁：房金波副教授生物化學(xué)與分子生物學(xué)免疫生化學(xué)歷碩士東北師范大學(xué)學(xué)位評(píng)定委員會(huì)2006年6月AbstractThymo

2、sincL1(Td1)，a28一aminoacidpeptidewi也anisoelectricpointof42andam01ecularweightof3108Da，isapeptidehomlonesecretedby血e幽a1ofh岫aIlthymusorga工1izationsTQ1isabiolo百calresponsemod湎cator，mainlyasthee11王lallcerofTlymphatici咖unesyst

3、emforthepatientswithiⅡ]吼unedeficienciesorcons訂ainedimmullesystenWhenpatientswcreinfectedwithcertainVirusessuchasHIV，HBVor訂eated、^Tithradiotherapyorchemotherapy，t11eimmLmesystemtendstobecompromisedandeVendes訂oyedandcallno

4、tkillcellscontainavirusorcancercellsTⅡ1caIlrestorethefhnctionofTlymphocyte，inducetllepfoliferationofthematureTcells，promotethelymphocytetogatherarou工ldc孤cerandpathogenytissueandacceleratethcgenerationof1ymphfactorsand1)，

5、111phaticfactorreceptors，t11uS鏟eatlye11hancepatiems’fesistancetotheVinlsandcancerBecauseofitsIen垂h(28aa)，theTⅡ1isdi街culttos刪hcsizebygencticengineeringmethods；thecurrentchemicalpmductsofTⅡ1areexpensive；Inaddition，wecanext

6、ractTⅡ1丘omanimalthymus，butthepurityandactivityarelo、versoitscliIlicalapplicationislimitedTbexplorethepossibilmesofmassproductionofTⅡlorsimilarbiologicalreactiVeproduct，wedesignedandconstructedtheftlsedexpressionplasmidof