25602.若干雜原子取代烯烴的合成研究

1、碩士學(xué)位論文若干雜原子取代烯烴的合成研究研究生：王麗娜申請學(xué)位：理學(xué)碩士學(xué)科專業(yè)：物理化學(xué)學(xué)位授予單位：浙江師范大學(xué)指導(dǎo)老師：楊元法朱鋼國論文提交日期：2014年5月REGIOANDSTEREOSELECTIVESYNTHESIS0FHETEROATOM—SUBSTITUTEDOLEFINSMasterCandidate：LinaWangDegree：MasterofScienceMajor：PhysicalChemistryDegre

2、eAwarding：ZhejiangNormalUniversitySupervisor：ProfYuanfaYang，GangguoZhuSubmissionDate：May2014I之EGIOANDSTEREOSELECnVESYNTHESIS0FHETEROATOMSUBSTITUrEDOLEFINSABSTRACTHeteroatom—substitutedolefinsplayapivotalimportantroleinor

3、ganicchemistry，andconsequently，theinterestinthesemotifshasbeenlongstandingHowever，theregio—andstereoselectiveformationofheteroatom—substitutedalkenesremainstobeexploredHerein，acoupleofmethodsforaccessingheteroatom—substi

4、tutedalkeneshavebeenrealized，bytheregioandstereoselectiveadditionofheteroatom—substitutedalkynesTheworkconsistsofthreeparts：FirstlyaPdcatalyzedstereospecifictransadditionofboronicacidstoynamideshasbeenachievedforthefirst

5、time，furnishing㈣一0t，13disubstitutedenamidesinhighyieldswithexcellentregio—andstereoselectivityItrepresentsthefirstPd—catalyzedIronsadditionofboronicacidstoalkynesSOfarApossiblemechanisminvolvingthepalladiumcarbeneinterme

6、diatehasbeenproposedtoaccountfortheunusualtransadditionThen，aPd—catalyzedc／sadditionbotanicacidstoynamideshasbeenrealizedtoprovide(z)僅，pdisubstitutedenamidesinexcellentregio—andstereoselectivityClearly，itprovidesacomplem

7、entmethodfortheacessofstereodefinedpolysubstitutedenamidesFinallyallironcatalyzedregioandstereoselectivechlorosulfonylationofaromaticchloroalkyneshasbeenachieved，givingc／s一1，2dichlorovinylsulfonesinsatisfactoryyieldswith

8、goodtoexcellentstereoselectivityItprovidesaneweffectiveprotocolforthesynthesisofthermodynarnicallyunfavorablec／sI，2dichloroalkenesKEYWORDS：heteroatom—substitutedolefins；ynamides；enamides；c／s一1，2dichlorovinylsulfones；Iron