11898.基于snp的qtl基因印記效應(yīng)的估計(jì)及檢驗(yàn)

1、分類號(hào)IJDC密級(jí)登開一暑哦；暑聲哮’碩士研究生學(xué)位論文基于SNP白tJQTL基因印記效應(yīng)的估計(jì)及檢驗(yàn)申請人：任杰學(xué)號(hào)：2111093培養(yǎng)單位：數(shù)學(xué)科學(xué)學(xué)院學(xué)科專業(yè)：應(yīng)用數(shù)學(xué)研究方向：應(yīng)用統(tǒng)計(jì)指導(dǎo)教師：馬維軍完成日期：2014年4月24日AbstractThispaperstudiestheproblemofestimatingandtestingtheQTL’Simprintingeffectbasedonsinglenucleoti

2、depolymorphism(sNP)Genomicimprinting(alsoknownasgeneticimprinting)representsthedifferencesfromDaternalandmaternalchromosomesorallelesinthefunctional，thusoffspringbydifferentparentswouldcausedifferentphenotypeswhenthesame

3、chromosomeorgeneticchanged，is齜linheritanceofnon—MendelianCurrently，genomicimprintinghasbeenconsideredplayinganimportantroleintheformofcomplexhumandiseasesandpathogenesisImprintingmechanismhasbecometheresearchingfocusofma

4、nygeneticdiseases，howeverwehaven’tknownsomeaspectssuchasthenumberolimprintedgenes、theirchromosomallocationaswellaStheinteractionswithothergenesorenvironments，whichlimitsouraccuracyofconcludingaboutthestructureandpathogen

5、esisofhumancomplexdiseasegenesComparingtothevariationofDNAgenetic，HeritableinformationismoreSUSceptiblebyenvironmentwithinthecontextofepigenetic，and1SmorepronetoOccurdynamicandreversiblechangesBrieflydifferentenvironment

6、factorshavedifferente飪I擾tstothephenotypeoftheorganismadvancedrepresentativetypeAccordinglystudyingIQTL’simprintingeffectinthisarticle，wetakeaccountofthatitsimpactnotonlybyasimpleadditive，dominanceandimprintingeffect，maya

7、lsobeaffect—edbyenvironmenteffect、theinteractioneffectsofgenesandenvironments，SOweestablishthemixedlinearmodelwithenvironmenteffectsinordertoachievethepurposeofexplainingstatisticalsignificanceofthehumancomplexdiseasesca

8、usedbVgenomicimprintingmoreeffectivelythisarticlewillapplytheBayesianstatisti—calmethodstoestimateandtestofQTL’SimprinteffectKeywords：Geneticimprinting；Environmenteffect；QTLenvironmenteffect；Mixedlinearmodel；MCMCmethodII