17236.碳?xì)浠罨磻?yīng)合成芳腈類化合物

1、分類號一UDC密級公開舅參廬夕擎碩士研究生學(xué)位論文碳?xì)浠罨磻?yīng)合成芳腈類化合物申請人：學(xué)號：培養(yǎng)單位：學(xué)科專業(yè)：研究方向：指導(dǎo)教師：完成日期：管丁輝2121184化學(xué)化工與材料學(xué)院有機(jī)化學(xué)藥物合成化學(xué)孫志忠教授初文毅副教授2015年3月23日AbstractAromaticnitrilesexistextensivelyinnaturalproducts，agrochemicalsandpharmaceuticalsThecyanogr

2、oupsaskeyintermediatesinthefineorganicchemistrycanbeeasilytransformedintootherfunctionalgroupsForthemoment，somedrawbacksexistinthecommonsynthesisofaromaticnitrilesincludingtheuseoftoxicreagentsandtheharshreactionconditio

3、nsDuetothemildreactionconditionsandthepreclusionofpreactivationforsubstances，directinggroupsassistedC_HactivationreactionhasemergedasanalternativeroutetopreparingnitrilesAnewNNbidentatedirectinggroupassisted，palladiumcat

4、alyzedC_HcyanationsystemhasbeendevelopedinthisthesisThederivatizationsofthepreparednitrileswerealsostudiedFirstlyaccordingtoC_Hactivation，thenewsubstratescontainingaN，Nbidentateacylaminogrouphavebeendesigned，andthesynthe

5、ticmethodofN。(naphthalene‘1一y1)picolinamideswasimprovedThirteenN一(naphthalene一1y1)picolinamidederivativesweresynthesizedwiththeoptimalconditionsTheimprovedmethodobtainedthedesiredproductinhighyieldunderasimplework—upoper

6、ationSecondlythenovelN，Nbidentatechelateddirectinggroupassisted，palladiumcatalyzedC_HcyanationsystemusingnontoxicK4HFe(CN)6ascyanidesourcehasbeendevelopedTheoptimalreactionconditionswasobtainedbyscreeningofcatalysts，oxid

7、ants，solvents，temperature，theequivalentsofK4Fe(CN)6andreactionatmosphereThirteennitrilesweresynthesizedwiththeoptimalcatalyticsystemTheuseofrelativenontoxicKnFe(CN)6allowedthereactionproceedunderamildandenvironmental—fri

8、endlyconditionThecyanationmechanismhasalsobeenspeclutedFinallythepreparednitrilesweretransformedintodifferentderivativesincludingtetrazolescarboxylicacidsandamidesThefurtherderivatizationcanbeeasilyprecededduetothehaloat