1，2o異丙叉基αd戊二醛1，4呋喃糖及其肟衍生物的合成

1、≮警瑤拶⑧天睪大謦碩士學(xué)位論文_用啊啊際●|喁臻Im日__學(xué)科專業(yè)：應(yīng)用化學(xué)作者姓名：劉云華指導(dǎo)教師：張衛(wèi)紅副教授I＆—zⅡ女J■Ⅱ62006年6月120一isopropylidene_旺Dpentadialdo1，4furanoscanditsoximcderivativesareversatileprecursorofbioaetivenaturalproductsandazasugarandmodifiedsugarsInthis

2、paperfiveofthederivativeswfflesynthesized12：5，6diOisopropylideneaDglucofuranosewassynthesizedfromD—glucosewiththeyieldof80％ThestereoconfigurationofC一3wasinvertedbytheCr03oxidation／NaB84reductioncontinuousmethodandtheyiel

3、dwas613％ThetreatmentprocedureofoxidationWassimplizedandthereactiontimeneededWasshortened30benzoyl1，2：5，6di0isopropylidene—aDallofuranoseandglucofuranoseweresynthesizedandthehydrolysisof30一bcnzoyl一1，2：5，6di0isopropylidene

4、俚Dallofurallo$ewerestudiedThecontinuousmethodofbenzoylationandhydrolysisWaSdemonstrated3O—benzoyl1，20一isopropylideneaDallofuranoseandglucofuranoseweresynthesizedwiththeyieldof665％and573％Theselectivelyhydrolysisof12：56一di

5、—O—isopropylideneaDalloforanoseandglucoforanosewerealsostudiedinthispaperThevicinalglycolcleavageoxidationof3—0一benzoyl120isopropylidene弘D一allofuranoseandglucofaranosousingsilicagelsupportedNal04wasachieved30benzoyl一1，2一

6、Oisopropylidene一0tD—ribopentadialdo一1，4furanosand3O一benzoyl1，20isopropylideneqDxylopentadialdol，4一furanosewereobtainedwiththeyieldof引0％and65O％Thestructuresofthealdehydecompoundswereconfirmedby1HNMRThismethodisefficientan

7、dfacile，andtheproductsobtainedarcpurecnougIlforfurthersyntheticoperationswithouttheneedforchromatography30一benzoyl一1。20一isopropylidenext—D—ribopentadialdo一1，4furanoseoximeandO—methyloximeand30一benzoyl1，20isopropylidene—a

8、—D—xylopentadialdo1，4fmnoseO—methyloximeWeresynthesized，andtheirstructureswereconfirmedbyJHNMRKeywords：12Oisopropylidene—aDribopentadialdo1，4一furanose；12—0一isopropylidene—n—D—xylopentadialdo一14一furanose；12Oisopropylidene