阿爾茨海默病、多灶性梗塞性癡呆與垂體-靶腺軸功能關(guān)系的研究.pdf

1、安徽醫(yī)科大學(xué)碩士學(xué)位論文阿爾茨海默病、多灶性梗塞性癡呆與垂體靶腺軸功能關(guān)系的研究姓名：周農(nóng)申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：內(nèi)科學(xué)（內(nèi)分泌與代謝?。┲笇?dǎo)教師：楊明功2002.5.1安徽醫(yī)科大學(xué)碩士學(xué)位論文Pituitary—AdrenalaxisandthyroiddysfunctioninAlzheimer’diseaseandMultiinfarctdementiaAbstractObejective：Toidentifypituitarya

2、drenalaxisfunctionchangeandthyroiddysfunctioninAlzheimer’diseaseandMultiinfarctdementiaMethods：Serumlevelsofcortisol(F)，adrenocorticotropichormone(ACTH)andtriiodothyronine(T3)，thyroxine(T4)，freeT3(F3)，freeT4(FT4)，thyroid

3、stimulatinghormone(TSH)weredeterminedbyAutomatedChemiluminescent’immunoassaysystemorradioimmunoassayfor11patientswithAlzheimerdisease(AD)23patientswithmultiinfarctdementia(MID)，28patientswithmulticerebral—infarction(MCI)

4、and23healthycont∞JsAdexamethasonetest(DST)wasperformedin4patientswithAD，9patientswithMID，7patientswithMCIResults：1)PatientswithAD，MIDshowedsignificantlyhighserumcortisolthanthosewithMCIandthosehealthycontrolsNosignifican

5、tdifferenceswelefoundinserumACTHamongAD，MID，MCIandhealthycontrolsDSTrevealed75％AD，778％MIDpatientswerenonsuppressors2)TheselumT3，F(xiàn)T3，F(xiàn)T4levelsinpatientswithAD，MIDandMClwerelowerthanthatinthecontrolgroupNosignificantdiffer

6、enceswerefoundinserumT4，TSHbetweenthreepatientsgroupsandthehealthycontr013)Amongthreepatientsgroups：threewerenosignificantdifferencesinserumT，，T4，TSH，F(xiàn)T4andACTHlevels；butserumFT3levelwaslowerinpatientswithMIDascomparedwi

7、thMCI，theserumcortisollevelwashigherinpatientswithADandMIDthanthosewithMCIandhealthycontr01Conclusions：Theseresultssuggestthatlowerthyroidhormonemightplayaroleinthepathophysiologicprocessot’AD；thefunctionstateandserumhor