大腸癌Fas、FasL表達與臨床病理、術(shù)后化療及預后的關(guān)系.pdf

1、第二軍醫(yī)大學碩士學位論文大腸癌Fas、FasL表達與臨床病理、術(shù)后化療及預后的關(guān)系姓名：袁克文申請學位級別：碩士專業(yè)：外科學（普外）指導教師：吳德敬付志仁2001.4.1第二軍醫(yī)大學畢監(jiān)論文ABSTRACTobjective：ToevaluatethesignificanceofexpressionofFasandFasLincolorectalcancerandtherelationshipbetweenexpressionofFas

2、andFasLanditsclinopathologicalfeatures，post—operationalchemotherapyandprognosisMethods：Followupwasmadeincolorectalcancerpatientsofdepartmentofgeneralsurgeryofchangzhenghospitalwhowereoperatedonin1993，andtheresultswereobt

3、ainedin52casesWeinvestigatedtheexpressionofFasandFasLbyimmunohistochemicalstaininginformalin—fixedparaffinembeddedspecimensofthese52patientsandother20formalcolorectaltissuesResults：ExpressionofFaswasdown—regulatedandexpr

4、essionofFasLwasup—regulatedincolorectalcancercomparedwiththeformalcolorectaltissue(P005)ExpressionofFasincolorectalcancerwasassociatedwithturnorstage，andexpressionofFasLwithtumorstage，lymphnodemetastasesandinflammatoryre

5、actionaroundtulnor(P005)，butnotwithotherclinopathologicalfeaturesPostoperationalchemotherapyhadabettereffectinpatientswithpostiveexpressionofFasthanwithnegative(PO05J)，andhadnostasisticalsignificancewithexpressionofFasPa

6、tientswithnegativeexpressionofFasLhadamorefavourableprognosisthanthosewithpositiverP005)Conclusion：expressionFasandFasLisoneofmechanismsofcolorectalcancerescapingfrombodyimmunefunctionandpromotingitsgrowth，invasionandmet