鹽酸苯達莫司汀及其衍生物的合成與表征.pdf

1、南昌大學碩士學位論文鹽酸苯達莫司汀及其衍生物的合成與表征姓名：張勝菊申請學位級別：碩士專業(yè)：有機化學指導教師：戴延鳳魏俊超20100611ABSTRACTABSTRACTChroniclymphocyticleukemia(CLL)isadiseaseofclonesproliferationofmalignantB—cellwhichcausedbyapoptosisItisshowedthatmaturesmalllymphocyt

2、esaccumulateexceptionallyinperipheralblood，bonemarrowandotherlymphoidtissuesHoweverthepathogenesisofCLLisstillnotfullyunderstoodAtpresent，therearethreemainwaysforthetreatmentofCLL，suchas：radiationtherapychemotherapyandau

3、tologousstemcelltransplantationChemotherapyconsistsofSsingledrugchemotherapycombinedchemotherapyandmonoclonalantibodiesandchemicalimmunotherapyBendamustinehydrochlorideisacompoundofcontainingpurineanalogueandalkylatingag

4、entsthatCandestroytheDNAinsideoftumorcells，whichinducingeellapoptosisItisforthetreatmentofthecasesthatCLLCan’tbecuredbyfirstlinetherapyofchlorambucilandtheinertBcellnonHodgkin’Slymphomathatdiseaseprogressin6monthsbyritux

5、imaborprogramwimrituximabThepurposeofthisresearchtopicistoimprovetheBendamustinehydrochloridesyntheticrouteandsynthesissomenewanaloguesThemaincontentsareasfollows：Chapterl：ThischapterdescribesthecurrentstageofCLLstherapy

6、theprogressoftreatment，aswellashydrochloricacidBendamustinecurrentdevelopmentstatusandclinicaleffectsChapter2：Atthispart，1wanttodesignanewsyntheticrouteofBendamustinehydrochloridebasedontheanalysisofexistingsyntheticrout

7、e，andthensyntheseChapter3：SynthesizefournewanaloguesofBendamustinehydrochlorideTheirkeyintermediatesandtargetcompoundsarecharacterizedby1HNMR‘’CNMRIRMSThefourcompoundsareasfollow：1：4一1一ethyl一5NN【bis(2chloroethyl)一amino]2

8、一benzimidazolyl一butyricacid；2：3一1ethyl5NN一[bis一(2’一chloroethyl)amino]2benzimidazolyl一propionicacid；3：3[1一phenyl一5N，N—Ibis(2’一chloroethyl)一amino]一2一benzimidazolylpropionicacid；4：3一【1methyl5N，N一[bis一(2’chloroethyl)amino]一2