肺鱗癌中TGF-β-,1-的表達(dá)與上皮間質(zhì)轉(zhuǎn)化關(guān)系的初步研究.pdf

1、南昌大學(xué)碩士學(xué)位論文肺鱗癌中TGFβ的表達(dá)與上皮間質(zhì)轉(zhuǎn)化關(guān)系的初步研究姓名：萬(wàn)安云申請(qǐng)學(xué)位級(jí)別：碩士專(zhuān)業(yè)：病理學(xué)與病理生理學(xué)指導(dǎo)教師：熊小亮20091201AbstractABSTRACTObjective：TostudytheexpressionandrelationshipofTGF13l，Ecadherinan，VimentinandtoinvestigatethecorrelationofTGF13tinducedepithel

2、ialmesenchymaltransitionofSquamouscellCarinomaofLungMethods：60patients’clinicpathologydataandparaffinblockswerecollectedTheexpressionofTGF13l、EcadherinandVimentinwasdetectedbyMaxVision刑immunohistochemieialmethodResults：l

3、、TheexpressionrateofTGF一13lproteinwassignificantlyhigherinSquarnous—cellCarinomaofLungtissuesthaninadjacentnoncanceroustissues(333％W166％，PO05)；TheexpressionofTGF一13linⅡI～ⅣofTNMstagingwashigherthanthatinI～lIofCanCCTtissue

4、Metastasisgroupwashi曲erthanmetastasesgroupLowdifferentiategroupwashigherthanmiddleandhi曲group(PO05)，whichwasnotrelatedwithgenderageandtumorsize2、TheexpressionrateofEcadherinproteinwassignificantlylowerinSquamous—cellCari

5、nomaofLungtissuesthaninadjacentnOllcanccroustissues(533％倦80％，PO01)；TheexpressionofE—cadherininmetastasisgroupWaslowerthanmetastasesgroup，andmiddleandhi曲differentiategroupwerelowerthanlowdifferentiategroupTheexpressionwas

6、n’trelatedwithgenderage，tumorsizeandTNMstaging3、TheexpressionrateofVimentinproteinwashigherinSquamous—cellCarinomaofLungtissuesthaninadjacentnon—canceroustissues(461％俗O％，P0O1)TheexpressionofVimentininmetastasisgroupWaShi

7、gherthanmetastasesgroupTheexpressionofVimentininIII～ⅣofTNMstagingWashigherthanthatinI～I(xiàn)IofCanCel“tissue(PO05)，whichWaSh’trelatedwithgenderage，tumorsizeanddifferentiation4、InSquarnous—cellCarinomaofLung，theexpressionofTGF

8、一13lWasnegativelycorrelatedtothatofE—cadherin(嚴(yán)O26，P=0046)，butpositivelycorrelatedtothatofVimentinprotein(嚴(yán)0331，P=0011)；inaddition，theexpressionofE—cadherinWasnocorrelatedtothatofVimentinprotein(嚴(yán)一0004，P=0973)Conclusion：