雙糖基胍基苯及糖基酰氨基硫脲環(huán)合產(chǎn)物的合成.pdf

1、新疆大學(xué)碩士學(xué)位論文雙糖基胍基苯及糖基酰氨基硫脲環(huán)合產(chǎn)物的合成姓名：田添申請學(xué)位級別：碩士專業(yè)：有機化學(xué)指導(dǎo)教師：曹玲華20070704新疆大學(xué)2007屆碩卜研究生畢業(yè)論文AbstractSubstitutedguanidinesarefoundinmanycompoundsofmedicinalinterestForexampletheyhaveshownastrongantihypertensiveeffect，declineblo

2、odsugarandantimicrobialactivity；somecontainingthiazolehavebeenreportedtoshowantitubercularantimalarialRecentlyguanidinecontainingsugarhaveattractedtheattantionofpharmaceuticalindustryguanidinecontainingsugarhaveexhibited

3、anti—influenzaandantiHIVInordertobroadenthesynthesisandactivityresearchofglycosylguanidine，wehavesynthesizedaseriesofnewglycosylguanidinecompounds，containingbisglycosyl，bisbenzothiazolylandbisguanidyl13，4Oxadiazolesarebr

4、oadlyusedasherbicides，growthhormone，bactedcides，effectiveinsecticidesandantiphlogisticThesulfonamidegroupR。S02NHⅣisacommonpharmacophorefoundinvariousbiologicallyactivemolecules，enzymeinhibitorsandreceptorantagonistsThein

5、troductionofsugarcoreintomedicineCalllowerthetoxicityandmakethemedicine，containingsugarcore，morebiodegradableinbodyTherefore，weexpecttorea／izereinforcementofphysiologicalactivitiesbymeansofcombiningtheglycosylandsulfonam

6、idewithL34oxadiazolesThestructureofAllcompoundssynthesizedwasconformedbvdataof1HNMRIR，MS(ESI)，andelementalanalysisThemainiyworksinthispaper：TheOprotectedglycosylisothiocyanatewasrefluxedwith1，4diaminobenzeneinCHCl3togive

7、1，4bis(Nglycosyl)thioureylenebenzeneThen14一bis[N(4／6一substitutedbenzothiazole一2y1)Nglycosylguanidino]benzeneswereobtainedbyreactionof1，4bis(Nglycosyl)thioureylenebenzenewith2amino4／6一benzothiazolesandHgCl2inthepresentofT

8、EAinDME2NglycosyINamidothioureasweresynthesizedbythereactionofNptoluenesulfonylL—aaminoacidhydrazideswithglycosylisothioeyanatesThentheNglycosylNamidothioureaswerecyclizedunderthesystemofHg(OAc)2／EtOHtoaffordaseriesofnew

9、compounds，2一ptoluenesulfonylaminoalkyl5一glycosylamino1，3，4一oxadiazolesTheinnovationsofthethesisarebasedonthefoflowsThereactionofglyeosylisothiocyanateswith1，4diaminobenzenegiveriseto3novelI，4_bis(Ⅳglycosyl)lhioureylenebe