新型氯蟲酰胺類似殺蟲劑的設(shè)計、合成與生物活性研究.pdf

1、南開大學(xué)碩士學(xué)位論文新型氯蟲酰胺類似殺蟲劑的設(shè)計、合成與生物活性研究姓名：劉智力申請學(xué)位級別：碩士專業(yè)：化學(xué)；有機化學(xué)指導(dǎo)教師：李正名201105Abstract一—————_———————————————_———_—————_——_—————_——__———’，————一AbstractOneofthelatestbreakthroughsinpesticideresearchistheR&Dofaseriesofcompoundst

2、argetingattheRyanodineReceptor(RyR)Beingoneclassofsuchcompounds，anthranilicdiamideswasdiscoveredbyDuPontin2000，whichwithitsnewtargetingmachanisms，inducestheactivitionofRyanodinereceptorteleaseendogeIlouScaldumstoreinallu

3、ncontrolledmannerRynaxyp)，r1MWasthefirstcommercializedcompoundfromsuchclass，whichbearsexceptionalactivityonabroadrengeofLepidopteraandhasnocrossresistancetoexistinginsecticides，withitsextraordinaryselectivitytotargetmach

4、enismsecuresitssafetytohumansandotheranimalsBasedonthestructureofRynaxyp—andthemoleculardesignapproachsudlasbioactivesubstructurecoordination41unreportednoVelcompounds，includingthreeseriesofanthranilicdiamidesanaloguesan

5、dtwoseriesofnewimermediates，weredesignedandsynthesizedThestructuresofallcompoundssynthesizedweredeterminedby1HNMR，IRMSandelementalanalysisorHRMSBvmeansoftheestabilshedinsecticidalactivityscreeningsystem，theinsecticidalac

6、tivitiesofthesenewcompoundsweresystematicallytestedTheresultsofthebiologicalassayshowedthatsomeofthemexhibitedgoodinsecticidalactivitiesagainstOrientalArmyworm(MythinmaseparataWalker)andCulexpipiellspallensAmongwhichbyin