The Correlation Between N-Terminal Pro--Brain Natriuretic Pepeide and Diastolic Function in Asymptomatic Patients at Risk of De.pdf

1、Objective: to identify the correlation between N-terminal pro-brain natriuretic peptide (NT-proBNP) with diastolic function in asymptomatic patients at risk of developing heart failure, and the role of NT-proBNP in ident

2、ifying diastolic dysfunction.
　　Methods: eighty patients (age 45 - 70 years) were selected based on history of hypertension, diabetes mellitus, and coronary artery disease. Patients with at least one risk factor for H

3、F were selected in this study. Patients were enrolled in this study from January to July 2011 in First Affiliated Hospital of Chongqing Medical University. Left ventricular (LV) diastolic function was measured by conven

4、tional Doppler and Tissue Doppler imaging (TDI) echocardiography of mitral annulus. Plasma NT-proBNP concentration was measured by immunoassay.
　　Results: There were 36 men and 44 women in this study. The mean age of

5、 patients was 58.8 years old. Hypertension was present in 78/80 patients (97.5％); diabetes in 32/80 patients (40％); and coronary artery disease in25/80 (31.3％). In transmitral pulsed-wave Doppler velocity measurement,th

6、ere was no significant difference of NT-proBNP between normal andimpaired relaxation (mild di;astolic dysfunction). Patients withpseudonormal filling (262.2±55.63 pg/ml) and restrictive like pattem(781.5±152 pg/ml) had s

7、ignificantly higher NT-proBNP level (p<0.0005).In TDI measurement, patients were grouped int0 3 groups based on E/E'ratio <8 (group 1), E/E' rati0 8-15 (group 2), E/E' ratio >15 (group 3). TheNT-proBNP level in group l w

8、as 47.54±34.08 pg/ml, group 2 was94.98±78.88 pg/ml, and group 3 was 781.5±152 pg/ml. There was goodcorrelation between NT-proBNP and E/F'latiaral (F063; p<0.0005).
　　Conclusion: NT-proBNP level increases; as left vent

9、ricular diastolicfunction decreases, and there was good ciorrelation between NT-proBNPwith E/E' ratio. Patient with moderate-severe diastolic dysfunction hadhigher NT-proBNP level. NT-proB:NP canncot be used for identifi