Survivin、PTEN在子宮肌瘤中的表達(dá)及其與肌瘤增殖活性的關(guān)系.pdf

1、蘭州大學(xué)碩士學(xué)位論文Survivin、PTEN在子宮肌瘤中的表達(dá)及其與肌瘤增殖活性的關(guān)系姓名：武孟香申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：婦產(chǎn)科學(xué)指導(dǎo)教師：高英敏王秀華20050501蘭州大學(xué)碩士學(xué)位論文Theexpressionofsurvivin、PTENandtheirrelationshipwiththeproliferativeactivityinuterineleiomyomaAbstractObjectiveThisstudywasde

2、signedtoinvestigatetheroleofsurvivinandPTENproteinsinthepathogenesisanddevelopmentofuterineleiomyoma(UL)andtheirconcisionwithleiomyomacell’SproliferativeactivityMethodsImmunohistochemicaltechnique(SP)andimageanalysiswere

3、usedtodetectthesurvivinPTENandKi67proteinsexpressionsin20normalmyometrium(NM)and40uterineleiomyomaResultsSurvivinproteinWaSexpressedin27of40patientswithuterineleiomyoma(675％)，thepositiveexpressionrateandexpressingintensi

4、tyofsurvivinproteininuterineleiomyomawereclearlyhigherthanthatinnormalmyometrium(z2=7576，p=0006r=4574p=O000)PTENproteinwasexpressedin33of40patientswithuterineleiomyoma(s25％)，theexpressingintensityofPTENproteininuterinele

5、iomyom8wassignificantlylowerthanthatinnormalmyometriumO7=8436，礦=o000)Ki67protein吣expresscdin30of40patientswithuterineleiomyoma(75o％)，thepositiveexpressionrateandKi67indexinuterineleiomyomawereclearlyhigherthanthatinnorma

6、lmyometrium∽=19394，p=0000；產(chǎn)7580，p=0000)Inuterineleiomyoma，theexpressionlevelofsurvivinproteinshowedapositiverelationwithKi一67index(產(chǎn)O823，p=0000)，th。eXpressionlevelofPTENproteinshowedanegativerelationwithKi67index(r=O679，