99m Tc HYNIC TOC IMAGING OF NEUROENDOCRINE TUMOURS IN CHILDREN-A SINGLE CENTRE STUDY.pdf

1、Aim: : There is a lack of literature on the imaging of neuroendocrine tumours in children so much so as imaging findings have been derived from adult studies. The aim of this study was to evaluate the use of 99mTechnetiu

2、m-Hydrazinonicotinyl-Tyr3-Octreotide (99mTc HYNIC TOC) for diagnosing and staging neuroendocrine tumours in children with special emphasis on the acquisition protocol including Single Photon Emission Computed Tomography

3、(SPECT) co-registration with Computed Tomography (CT).
　　Method: 22 patients (15 boys, 7 girls;Age Range:46 days-9 years;Mean age=2.08 years) underwent 99mTc-HYNIC-TOC whole body scintigraphy (early and late stage) an

4、d regional SPECT/CT post intravenous injection of 10mCi of the radiopharmaceutical. Images were evaluated both qualitatively and semi-quantitatively by two experienced nuclear medicine physicians and results compared wit

5、h those of conventional imaging. Histopathology results and conventional imaging with biochemical markers were considered as reference standards.
　　Results: Whole body planar scans and SPECT/CT imaging were found to b

6、e superior to conventional imaging modalities for detection of primary tumours and metastases with a sensitivity of 82.4%, specificity of 80%and accuracy of 81.8%. Neuroblastomas were the most common neuroendocrine tumou

7、r diagnosed (77.3%).
　　Conclusion: 99mTc HYNIC TOC imaging appears to be highly useful in improving detection of neuroendocrine tumours and metastases in children. It can significantly impact on patient management and