肝硬化數(shù)據(jù)挖掘

1、Comparison of AI Techniques for Prediction of Liver Fibrosisin Hepatitis Patients,Journal of Medical SystemJiajun Shi,Some explanations,Fibrosis - 纖維化Hepatitis - 肝炎Hepatitis B/C – 乙肝/丙肝Cirrhosis – 肝硬化Liver biops

2、ies - 活組織檢查Non-invasive techniques – 無創(chuàng)技術(shù)Serum markers – 血清標(biāo)記,Outline,IntroductionBackground: AI and CDSSNaïve Bayes Classifier (NBC) & Logistics RegressionHepatitis and Fibrosis StageAI Assisted Web-based

3、 Clinical Decision Support SystemFour MethodsResults and Diagnostic AccuracyConclusion,Introduction,One in twelve people have the Hepatitis B or Hepatitis C virusDiagnosis and treatment of this disease is guided by l

4、iver biopsies where a small amount of tissue is removed by a surgeon and examined by a pathologistDetermine the fibrosis stage from F0 (no damage) to F4 (cirrhosis),Risk and costly,Non-invasive techniques, with serum ma

5、rkers, imaging test, and genetic studies,Accuracy not achieved sufficient acceptance,Introduction,Non-invasive techniques, with serum markers, imaging test, and genetic studies,AI & CDSS,Knowledge of the level of liv

6、er damage in a patient withliver disease (particularly Hepatitis B and Hepatitis C) is acritical factor in determining the optimal course of treatmentand to measure the effectiveness of alternative treatments inpatie

7、nts.,Not accurate,Background of AI and CDSS,Artificial Intelligence and Data Mining techniques Include Neural Networks, Fuzzy Logic, Decision Trees, Bayesian Classifiers, Support Vector Machines, Genetic Algorithms and

8、Hybrid System,Clinical and Medical Decision Support SystemsSupport the process of discovering useful information in large clinical repositories They had done the system designed with neural networks and decision tree m

9、ethods because of their successful application in similar problem domains,Hepatitis and Fibrosis Stage,One in twelve people have the Hepatitis B or Hepatitis C virus,AI Assisted Web-based Clinical Decision Support System

10、,AI Assisted CDSS,AI techniquesResulting knowledge base,AI Assisted Web-based Clinical Decision Support System,Variables：,SerumMarkers,PatientsInfo,AI Assisted web-based Clinical Decision Support System,System inputs

11、& Outputs:,Four Methods,Paper ‘Advanced Decision Support for Complex Clinical Decisions’ Neural Networks, Decision TreesThis paperNaive Bayes and Log Regression,Method inputs:,Four Methods – Naïve bayes clas

12、sifier,The variation in mean values for two parameters (ABL and G-GL) are shown by fibrosis stage in the Figure.With this model, we can calculate the combined probability of each fibrosis stage then select the highest p

13、robable as our predicted result.,Four Methods - Logistics regression,Cross Validation and Diagnostic Accuracy,Cross Validation and Diagnostic Accuracy,Accuracy of Fibrosis Stage Predictions (424 patients),Predictive Sens

14、itivity and Specificity,Conclusion,The four artificial intelligence methods presented in this study showed some significant variability in accuracy, sensitivity, and specificity in predicting fibrosis stage in data on 42

15、4 hepatitis patients. Although neural network methods showed the highest sensitivity and specificity, their role is predicting the exact fibrosis stage was relatively poor. Logistic regression and naïve bayes meth