紅花黃色素注射液論文紅花黃色素注射液膜性腎病基質(zhì)金屬蛋白酶抑制物基質(zhì)金屬蛋白酶

1、<p>　　紅花黃色素注射液論文：紅花黃色素注射液對Heymann大鼠的保護(hù)作用以及對腎組織中基質(zhì)金屬蛋白酶系統(tǒng)的影響</p><p>　　【中文摘要】:本研究通過應(yīng)用陽離子化牛血清白蛋白(C-BSA)誘導(dǎo)出Heymann大鼠模型,以鹽酸貝那普利為對照,探討紅花黃色素注射液對heymann大鼠的保護(hù)作用及對MMP-7、TIMP-1的影響,從而為其臨床上治療原發(fā)性膜性腎病提供實(shí)驗(yàn)基礎(chǔ)和理論支持。方法:選用

2、健康雄性SD大鼠40只,適應(yīng)性飼養(yǎng)一周,化驗(yàn)?zāi)虻鞍钻幮?隨機(jī)選取十只作為正常對照組,其余三十只SD大鼠尾靜脈注射C-BSA復(fù)制Heymann大鼠模型,每周三次,連續(xù)注射4周后,化驗(yàn)24小時(shí)尿蛋白定量,確認(rèn)造模成功后,將三十只heymann大鼠隨機(jī)分為模型組、貝那普利治療組、紅花黃色素治療組三組,每組各十只大鼠,貝那普利治療組給予鹽酸貝那普利10mg?kg?d灌胃,紅花黃色素治療組予以紅花黃色素注射液26.7mg/(kg·d)腹

3、腔注射,正常組及模型組灌服等量的生理鹽水,各組大鼠正常進(jìn)食進(jìn)水,連續(xù)給藥四周。檢測尾靜脈注射C-BSA四周后及給藥治療四周后大鼠24h尿蛋白定量。檢測實(shí)驗(yàn)?zāi)└鹘M大鼠血清總蛋白(TP)、白蛋白(ALB)、總膽固醇(TC)、甘油三酯(TG)、尿素氮(BUN)、肌酐(Scr),隨后將大鼠處死,留取腎組織,光鏡</p><p>　　【英文摘要】:We product Idiopathic Heymann rat anim

4、al model by C-BSA.Proteinuria plasma protein,blood-fat,renalfunction,renal pathomorphology,the expression of renal TIMP-1 and MMP-7 mRNA were observed.The effect and mechanism of the safflower yellow injection on Idiopat

5、hic Membranous Nephropathy were investigated so as to explore the mechanism.Method: Forty male SD rats were used in this study.Ten of them were randomly assigned to the normal control group. Others were used to duplicate

6、 the MN model b</p><p>　　【關(guān)鍵詞】紅花黃色素注射液 膜性腎病 基質(zhì)金屬蛋白酶抑制物-1(TIMP-1)mRNA 基質(zhì)金屬蛋白酶-7(MMP-7)mRNA</p><p>　　【英文關(guān)鍵詞】The safflower yellow injection Idiopathic Membranous Nephropathy TIMP-1mRNA MMP-7mRNA<

7、;/p><p>　　【目錄】紅花黃色素注射液對Heymann大鼠的保護(hù)作用以及對腎組織中基質(zhì)金屬蛋白酶系統(tǒng)的影響摘要4-7ABSTRACT7-10前言11-12材料與方法12-16結(jié)果16-19附圖19-32附表32-36討論36-39結(jié)論39-40參考文獻(xiàn)40-45綜述