血清內(nèi)脂素水平與妊娠糖尿病臨床相關(guān)性研究.pdf

1、內(nèi)蒙古醫(yī)學院碩士學位論文血清內(nèi)脂素水平與妊娠糖尿病臨床相關(guān)性研究姓名：路青玉申請學位級別：碩士專業(yè)：內(nèi)科學指導教師：李子玲201005019ResearchofclinicalcorrelationbetweentheserumvisfatinlevelandgestationaldiabetesmellitusObjectiveToevaluatetheroleofvisfatiningestatioaaldiabetesmellit

2、us，wedeterminedvisfatinlevelsinwomen而thGDM(gestationaldiabetesmellitus)andinhealtbypregnantcontr01Furthermore，therelationshipofserumvisfatinlevelsandmetabolicorbioehemi—calindicatorsintheGDMwereinvestigatedMethod11曲women

3、析tIlGDMand30healthypregnantcontrolswereincludedinthestudyFastingserumleveLsofvisfatinweremeasurediIlatlsubjectsMeanwhileblood—lipid，fastinginsulin(FINS)，fastingplasmglueo北(FPG)，C—pepdde(C—P)weremeasuredandbodyⅡlassinde(B

4、MI)，homeostasismodelofinsulinresistance(HOMA—IR)，insulinsensitivityindex(si)，modifiedB—cellfunctionindex(MBCI)werealsocalculatedThecorrelationbetweentheserumvisfatinlevelsandthemetabolicandbiochemicalindictorswas羽珀惻bySPS

5、S115softwareforwindowsResultsTheserumvisfatinlevelsinGDMp撕entswereoutstandinglyhigherthanthoseinhealthypregnantcontrol(P001)Acorrel丑tionanalysisshowedthatthe8erumvisfatinlevelsWaspositivelycorrelationwitllFPG，F(xiàn)INS，c—P，HO

6、MA—IR，MBCI(P005orPO01)andnegativelycorrelationwithISIrespectively(P001)ConclusionThefastingserumvisfainhveLsinGDMincreasedandthefastingplasmavisfatinlevelsispositivelyrehtedtoFPG，F(xiàn)INS，HOMA—litandnegativelycorrelationwith