FHIT、hTERT蛋白在皮膚鱗狀細胞癌中的表達及意義.pdf

1、青島大學(xué)碩士學(xué)位論文FHIT、hTERT蛋白在皮膚鱗狀細胞癌中的表達及意義姓名：王松芬申請學(xué)位級別：碩士專業(yè)：病理學(xué)指導(dǎo)教師：項鋒鋼20120602TheexpressionandsignificanceofFHITandhTERTinsquamouscellcarcinomaofskinAbstractObjectiveTodetecttheexpressionoffragilehistidinetriad(FHIT)andhuman

2、telomerasereversetranscriptase(hTERT)proteinamongSquamouscellcarcinoma(SCC)。Bowen’Sdisease(BD)，Solarkeratosi(SK)andnormalskintissues，andtOexploretherelationshipbetweenFHIT、hTERTandtheoccurrenceandprogressioninSCCMethodsT

3、heexpressionofFHITandhTERTwasdetectedimmunohistochemistricallybyPV6000methodin50casesofSCC，20casesofBD，15casesofSKand10casesofnormalskinResults①nepositiveexpressiverateofFHITinnormaltissue，SK，BDandSCCwasl00O％，733％，550％an

4、d44O％respectivelyThecomparisonbetweennormaltissueandBD、sccC=6429、10500)，SKandsccC=3972)，wellandpoordifferentiation(礦=4。020)，lymphnodemetastasisornot(礦=4。788)allhadsignificantstatisticdifference(pO05，respectively)②Therewa

5、snoexpressionofhTERTin10casesnormalskinmpositiveexpressiverateofhTERTinSKBDandSCCwas400％，700％and800％respectivelyThecomparisonbetweennormaltissueandSK，BD，SCC(po05，respectively)，SKandSCC(f。8924)，wellandpoordifferentiation(

6、f=4861)，lymphnodemetastasisornot(3(z=3947)，allhadsignificantstatisticdifference(p005，respectively)Therewas110significantstatisticdifferencebetweenSKandBD，BDandSCC@O。05)③Inlllesameeasethehigherofthepositiverateandtheposit

7、iveexpressiveintensityofFHIT，thelowerofhTERTIntheskinsquamouscellcarcinomatissues，theexpressionofFHITproteinWasnegativelycorrelated謝tlthehTERTprotein(產(chǎn)0363，P=O010)Conclusion①ThedecreasedexpressionofFHITmayrelatetooccurre

8、nceandprogressionofSCC②TheincreasedexpressionofhTERTmayalselatetooccurrenceandprogressionofSCC③TheexpressionofFHITWaSnegativelycorrelatedwiththehTERTindicatesthatantagonisticeffectmayexistintheoccurrenceandprogressionofS