二甲雙胍治療多囊卵巢綜合征伴胰島素抵抗患者的療效觀察.pdf

1、青島大學碩士學位論文二甲雙胍治療多囊卵巢綜合征伴胰島素抵抗患者的療效觀察姓名：李曉林申請學位級別：碩士專業(yè)：婦科學指導教師：孫寶治20050514ClinicalobservationofmetforminintreatmentofpatientswithpolycysticovarysyndromeandinsulinresistaneeAbstractObjectiveTostudytheeffectsofmetforminontr

2、eatingpatientswitllpolycysficovarysyndrome(Pcos)andblsulinresistance(R)，Methods30patientswjmPCOSandIRwereselectedasstudygroupand30normalwomenascontrolgroupTheclinicalsymptoms，reproductivehormones，suwnmglucoseandinsulinle

3、velswereobservedAttheendof12weektherapywithmefformin，subjectswerereevaluatedandaboveparametersweremeasuredinstudygmupResultsTllestudygrouphadmarkedlyhigherlevelsinbodyiTIaSSindex(BMI)waist／hipratio(WHR)，F(xiàn)errimenGallweySC

4、Ore(FGscore)，luteinlzinghormone4H)，luteiulzinghormone／folliclestimulatinghormone(LH／FSH)，testosterone(T)，freetestosterone(FT)，androstenedione(A2)，dihydroepiandrosteronesulfate(DHEAS)，fastingbloodghicose(FBG)，tastinginsul

5、in(FINS)，insulinresistancehomamodel(Homa墩)，HomaBcall，areaundercurveglucose(AUC。)，@／caundercnrveinsulin(AUCOthanthecontrolgroup(P0001一O05)Thestudygrouphadmarkedlylowerlevelsinsexhormonebinding酉obulin(SHBG)，insulingrowthfa

6、ctorbindingprotein1(IGFBP一1)，insulinsensitivityindex(ISl)thanthecontrolgroup(PO，05)TheotherswerenotsignificantlydifferentbetweentwogroupsAfteradministrationofmefforminfor12weeksinthestudygroup，22of30(73％)casesrecoveredov

7、ulationand4of30(13％)casesobtainedpregnancyBMIW玎tFGscore，LH，LH／FSH，衛(wèi)FT，A2，DHEAS，F(xiàn)INS，HomaIR，HorrmBcell，AUCaAuClweredecreasedsignificantly(PO01—005)andSHBGIGFBP1，ISlwereincreasedsignificantlyaftertreatment(P0。05)。Nodiffere