腎細胞癌的CT征象與PCNA、VEGF表達和MVD的關(guān)系研究.pdf

1、分類號UDC密級學(xué)號Y940719延邊大學(xué)碩士(博士)學(xué)位論文腎細胞癌的CT征象與PCNA、VEGF表達和MVD的關(guān)系研究研究生姓名宣薯艮實培養(yǎng)單位壁追大學(xué)匡院指導(dǎo)教師姓名、職稱熬熹梅熬攮學(xué)科專業(yè)影像羼茉與撅醫(yī)學(xué)研究方向腎紐咆癌論文提交日期!∞年蟲用強目碩士學(xué)位論文ThecorrelationbetweenexpressionsofVEGF、PCNAcellcarcinomaPostgraduate：XuyinshiCTfeatures

2、andandMVDinrenalTutor：ZhaozhinleAbstractObjective：ToevaluatethecorrelationbetweenCTfeaturesandexpressicnsofVEGF、PCNAandMVDinrenalceilcarcinoma(RCC)Methods：Forty—onepatientswithRCCdiagnosedbypathologyunderwentSCT(spiralCT

3、usedtheAsteionMSCT)examinationsandexpressionsofVEGF、PCNAandMVDwereexaminedimmunohistochemicallyusingthePCI0cloneThe41patientswereexaminedplainCTscanthentheywereinjectedcontrastmediaLohexolinjection(300mg／m1)(15ml／kgweigh

4、t)inmediancubitalveinat3Om／sCorticomedullaryphase(CMP)scanwasrerformedaftertheinjection30sandNephrographicphase(NP)scanwasafterit90sthescanparameter：120KVP250mAspitch35CTimagineswereobservedfortumorsize，intratumornecrosi

5、s，Liquefaction，cysticdegeneration，enhancementheak，margin，perienalfatinfiltration，lymphnodesmetastases，invasionofrenalveinorinferiorvenacava，invasicnofadjacentorgansordistantmetastasesandcomparedwiththeimmunohistochemical

6、resultResults：1Theaccuracyofdetectionandcharaterizationandstagein41RCContwo—phaseenhancedSCTscanswere100％，100％，and94％respectively2In41casesofRCCthenloanMVDwas8780389l／kenThepositiveexpressionofVEGFwas756％andPCNAwas100％，3

7、ThepositiveexpressionofVEGFPCNAweresignificantlycorrelatedwithperirenalfatinfiltration，lymphnodesmetastases，invasionofrenalveinorinferiorcava，invasionofadjacentorgansordistantmetastasesonCTscan(pO05)，atthesametimewerecor

8、relatedwithMVD4Asnucleargradeincreased，RCCsweremerelibelytobepositiveVEGFandPCNAexpressionandMVDenhance(pO05)5MVDandtheexpressionsofVEGFshowedapositivecorrelationinrenalcellcarcinoma(relatedparameterr=0497p001)Conclusion