惡性腫瘤病人血漿TM，PC抗原及DD含量測(cè)定的臨床意義.pdf

1、青島大學(xué)碩士學(xué)位論文惡性腫瘤病人血漿TM，PC抗原及DD含量測(cè)定的臨床意義姓名：楊忠思申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：臨床檢驗(yàn)診斷學(xué)指導(dǎo)教師：譚齊賢汪洪毅2002.4.1英文摘要THECLINICALSTUDY0FPLASMATHROMBOMODULIN，PROTEINCANTIGENANDD—DIMERINMALIGNANTTUMORSABSTRACTObjectiveTostudythelevelsofplasmathrombomoduli

2、n(TM)，proteinC(PC)antigenandDdimer(DD)beforeandaftertreatmentinacute1eukemiaandsolidtumorpatients，andtoexploretheirsignificanceinthedevelopment，curativeeffectandprogno—sisofleukemiasandsolidtumorsMethodsTwentytwoleukemia

3、andfortyonesolidtumorpatientswereselectedintothestudy，thelevelsofplasmathrombomodulin，proteinCantigenandDDweremeasuredbvELISAResultsComparedwithnormalcontrolgroupplasmalevelsofTMandDDwereelevatedandplasmaPCantigenlevelsw

4、erereducedbeforetreatmentinacuteleukemiapatients(￡=3509—6077，P0，01)Aftercompleteremission，plasmalevelsofTMandPCantigenreturnedtonormalrangeexceptfornDcomparedwithnormsleontrolgroup(t=3509，P001)PlasmalevelsofTMandDDwereel

5、evatedandplasmaPCantigenlevelswerereducedbeforeoperationinsolidtumorpatientscomparedwithnor—realcontrolgroup(t=2586—9000，P005)Sevendaysafteroperation。plasmalevelsofTMdecreasedtOnormalrange，butplasmalevelsofDDincreasedand

6、plasmalevelsofPCdecreasedfurtherThereweredifferencesbetweenthethreeguoups(I，1I，Ⅲ)ofhepatocarcinomaplasmalevelsofTMandDDincreasingandPCdecreasingwithup—gradingofthestageButtherewasnodifferencebetweenthesethreemarkersafter

7、treatmentConclusionActivationofcoagulationandfibrinolysisexistedinpatientswithma—lignanttumorsaswellasinjuryofvascularendothelium，andweregreatlyimprovedwithameliorationofthediseaseTheplasmalevelsofTM，PCantigenandDDcanbeu

8、sedasoneoftheindicatorsofthedevelopment，curativeeffectandprognosisofmalignanttumorsKEYWORDS：leukemia；neoplusmus；thrombomodulin；proteinClDdlmerPostgraduate；YangZhongsi(ClinicalLaboratoryDiagnostics)Directedby：TanQixianWan