國人小兒異丙酚靶控輸注系統(tǒng)的建立和準(zhǔn)確性評價(jià).pdf

1、溫州醫(yī)學(xué)院碩士學(xué)位論文國人小兒異丙酚靶控輸注系統(tǒng)的建立和準(zhǔn)確性評價(jià)姓名：劉華程申請學(xué)位級別：碩士專業(yè)：麻醉學(xué)指導(dǎo)教師：連慶泉徐旭仲20050301些型墮蘭墮堡土里窒生蘭堡墾苧一一SetupandevaluatetheaccuracyoftargetcontrolledinfusionsystemforpropofolinChinesechildrenAbstractObjectiveTosetuptheChinesechildrenta

2、rgetcontrolledinfusionsystemincorporatedpharmacokineticparametersbyLIANQingquanToanalyzethedifferencebetweentargetandmeasuredconcentrationsofpropofolgivenbytargetcontrolledinfusion(TCI)andevaluatetheaccuracyoftheTCIsyste

3、mforChinesechildrenMethodsTheTCIsystemwascomposedofSamsungQ20pocketcomputerGraseby3500infusionpump，Stanpump(Version10)andpharmacokineticparametersbyLIANQingquanTwentyfourpediatricpatientsinASAIscheduledforelectivesurgery

4、undergeneralanesthesiawereenrolledinthisstudyTheyweredividedintotwogroups：groupAaged一5yrand12yrfn=12)Thepatientswerepremedicatedwithatropine002～O03mgkg一1andimidazotam01t02mgkg一1andketarnine2～4mgkg一、intramuscularlyifitisn

5、ecessaryIntubationwasfacilitatedwithvecuronium01mgkg～AnesthesiawasmaintainedwithisofluraneandTCIofpropof01Thetargetplasmaconcentrationwassetat3ug‘ml～TCIofpropofolwasmaintainedforlhandbloodsamplesweretakenat13，5，10，20，30，

6、40，50，60，625，65，70，80，90minMAP，HR，CVP，ECG，Sp02andPETC02werecontinuouslymonitoredwithinanesthesiaTheplasmapropofolconcentrationwasdetectedbyHPLCThemedianperformanceerror(MDPE)，meanabsoluteperformanederror(MDAPE)，wobbleand

7、divergencewascalculatedusedforappreciationthissystemResultsDuringTCIperiod，therewasaremarkableinitialovershotatthefirstfiveminutesComparedwithtargetconcentrations，themeas_11redconcentrationsofpropofolweresignificantlyhig

8、herduringTCIbutlowerafterTCI(po05)During60minutesofTCI，MDPE，MDPE[，MDAPE，wobbleanddivergenceingroupAwere2700％，700％，2700％，2317％，一t31％’h_‘respectivelyand2567％，1200％，2567％，2350％，146％h。respectivelyingroupB30minutesafterTCI，MD