腫瘤-睪丸抗原MAGE-1和NY-ESO-1mRNA在胃腸間質瘤中的表達及其臨床意義.pdf

1、南昌大學醫(yī)學院碩士學位論文腫瘤睪丸抗原MAGE1和NYESO1mRNA在胃腸間質瘤中的表達及其臨床意義姓名：賴斌申請學位級別：碩士專業(yè)：外科學指導教師：朱培謙20100601AbstraetABSTRACTAIM：ToinvestigatetheexpressionofMelanomaantigen1(MAGE1)andNewYorkesopHageal一1(NYESO1)mRNAinthetissuesofgastrointestin

2、alstromaltumors(GISTs)，todiscussthepossibilityandtheclinicalsignificanceofMAGE1andNYESOIantigensusedasspecifictargetsfortheimmunotherapyofGISTs，andtoevaluatethepossibilityofMAGE1andNYESO1mRNAusedasauxiliarygradingcriteri

3、aforGISTsdangerousnessMethods：MAGEIandNYESOImRNAweredetectedbyreversetranscriptasepolymerasechainreactionintissuespecimensoftumorin30patients、析thGISTsThepathologicaldatawereretrospectivelyanalyzedResults：TherateofMAGE1an

4、dNYESO1mRNAexpressionwas334％and466％respectivelyintumortissuesofGISTs，18casesofGISTstissuesweredetectedatleastoneofthesetwoCTAsTheexpressionofMAGE1andNYESO1mRNAWasunrelatedtoage，sexorpathologytype(PO05)，butrelatedtotheori

5、ginalsite，tumordiameterandthebiologicalpotentialgrading(P005)Conclusion：(1)MAGE1andNYESOlmRNAwereexpressedwithahighspecificityinthetissuesofGISTs，thustheirantigensmightbepotentiallypromisingtargetsforantigenspecificimmun

6、otherapyofGISTs(2)TheexpressionofMAGEIandNYESO1mRNAwerecorrelatedwiththegrading—criteriaofGISTsdangerousnessMAGE1andNYESO—lmRNAarethepromisingauxiliaryindextodiagnosetheGISTsdangerousnessKeyword：Gastrointestinalstromaltu