米非司酮與GnRHa預(yù)防內(nèi)異癥術(shù)后復(fù)發(fā)的療效觀察.pdf

1、新疆醫(yī)科大學(xué)碩士學(xué)位論文米非司酮與GnRHa預(yù)防內(nèi)異癥術(shù)后復(fù)發(fā)的療效觀察姓名：王婧申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：婦產(chǎn)科學(xué)指導(dǎo)教師：丁巖2009-04新疆醫(yī)科大學(xué)醫(yī)學(xué)碩士學(xué)位論文 新疆醫(yī)科大學(xué)醫(yī)學(xué)碩士學(xué)位論文 —2—Clinical observation on the effects of mifepristone and GnRH-a for postoperative pelvic endometriosis Postgraduate:

2、wangjing Supervisor: Prof. dingyan Abstract Objective ： To evaluate the efficacy and side effects of mifepristone and GnRH-a on endometriotic patients after conservative surgery. Methods:one hungerd and fifty women w

3、ith moderate or severe endometriosis after conservative surgery were divided into three groups: mifepristone group (60 cases,mifepristone 10mg/d, 3 months) ; gonadotrop in releasing hormone agonist (GnRH- a) group (52 c

4、ases, hypodermically leuprorelin acetate 3.60 mg, once per twenty - eight days for 3 months) ; control group (38 cases) did not receive any postoperative medical treatment. Recurrence rate and adverse effect rate were co

5、mpared among these groups. Side-effects were recorded after treatment. Results：Pelvic pain and uterine cramping of all patients were relieved; both mifepristone group and GnRH-a treatment group achieved significant relie

6、f of pelvic symptoms and signs (65.0% and 71.0% ) than that(52.6%) of the control group ( P 0105).The recurrence rates of mifepristone group and GnRH-a group were5.0% and 3.8% ,respectively,significantly lower than that(

7、21.1%) of control group (P < 0. 05,). The adverse effect rate of mifepristone group was 25.0% , which was significantly lower than that of GnRH-a group (57.6%) (P < 0. 05). Conclusion：Mifepristone and GnRH-a are ef