納米載銀抗菌劑的研究及其在PMMA義齒基托中的應用.pdf

1、蘭州大學碩士學位論文納米載銀抗菌劑的研究及其在PMMA義齒基托中的應用姓名：王建榮申請學位級別：碩士專業(yè)：口腔臨床醫(yī)學指導教師：劉斌呂晉軍20100501蘭州大學碩十學位論文AbstractThepaperwhichwasaimedatthedevelopmentofnewbiomaterialsformedicalantibacterial，usedin—suitreductionandionexchangemethodtoprodu

2、ce。Silvercarringnano—antibacterialagentandtostudyitsphysicalandchemicalproperties，antibacterialactivityandcelltoxicityFurthermore，thisnewagentwasappliedtoPMMAdenturebaseDetectingthesilvercarringantibacterialagent／PMMAcom

3、positesmaterial’Sphysicalandchemicalproperties，antibacterialactivityandcelltoxicitywenotonlyproposedanewapproachofmodificationondenturebasematerial，butalsomadethecompositesmateriallaythefoundationforclinicalapplicationMa

4、incontentsandconclusionsareasfollows：(1)Weusedtheinsuitreductionmethodtomakesurethatthe8～1lnmnanosizesilverparticlesweresuccessfullyloadedtothesurfaceofATPtreatedbythi01Elementalanalysisshowedthatthesilvercontentwasupto9

5、13％XRDandFTIRanalysisshowedthatthestructureofATPhasnotchangedbeforeandaftertheAgwascarriedXPSshowedthatAgexistedin2forms：silverandsilverionsTheantibacterialtestandcelltoxicitytestshowedthatsilver—carringATPhasgoodantibac

6、terialabilityandbiocompatibility(2)Usingtheionexchangemethod，wemadetheAgcarryingzeoliteantibacterialagentSEMshowedthisagentparticleswereinirregularshape，andtheparticlesizewasinconsistent，mainlyabout1～29mElementcontentind

7、icatedthatthesilvercontentwasabout18wt％XRDindicateedthattheagenthasobviouscrystalstructure，F(xiàn)TIRprovedthattheAg—carryingzeoliteantimicrobialagentwasakindofrelativelypureinorganicantibacterialagentandhasnonootherorganicimp

8、uritiesTheantibacterialtestandcelltoxicitytestshowedthatsilverearringzeoliteagenthasgoodantibacterialabilityandbiocompatibilitySowecanprovideagoodtheoreticalbasisabouttheapplicationofAgcarryingzeoliteantibacterialagentin