多孔β-TCP陶瓷藥物載體的制備及性能研究.pdf

1、武漢理工大學(xué)碩士學(xué)位論文多孔βTCP陶瓷藥物載體的制備及性能研究姓名：張啟煥申請學(xué)位級別：碩士專業(yè)：材料學(xué)指導(dǎo)教師：閆玉華20040501武漢理工大學(xué)碩士論文_____●___●_—__——__—___●____———___●_——________●—————————ABSTRACTDrugcarrieriswidelyusedforitcancontroldrugrelease，maintainhigherdmgconcentrati

2、oninlocalarea，dolittleharmtonormalstructure。Itmaybeclassifiedintopolymericcarrierandinorganiccarrieraccordingtothedemandofitsoperationplace。Inthecureofosseoustissueaffection，inorganiccarrierarecommonlyused?？谝籺ricalciumph

3、osphate(13一TCP)applyinorthopaedicsembeddedmaterialextensivelybecauseofitsdegradabilityandgoodbiocompatibility。Inthearticle，wemadeporous8TCPceramicsdrugcarrier。Intheprocessofpreparation，WehaveB—TCPasthebasalmaterial，thena

4、ratioofbinderandparaffinareaddedintothepowderofTCPslipcastingbyhot—pressing，moldunloading，sintering。Inourexperiment，thepowderof13TCParepreparedbysolidphasereactiontheresultofXRDshowsthe13一TCPmadebythismethodispureIntheco

5、urse，thecontentofbinderarecontrolledintherangeof20％25％，thecontentofparaffinrangedfrom40％45％，sinteringtemperaturerangedfrom900。C～950。C。Withinthelimitsofaboveparameter，differentsamplesaremade，thenitsobviousporosity，permeab

6、ility，density，compressivestrengtharemeasuredTheresultsshowedobviousporosityrangefrom40％一65％，densityfrom1411539／cm3permeabilityfrom2。110“mm23310“nlm2，compressivestrengthfrom3，865Mpa，comparetheirphysicalperformancedifferen

7、ce，wecandrawaconclusion：morebinderlessparaffin，highersinteringtemperatureareavailabletodensityandcompressivestrength：onthecontrast，lowersinteringtemperature，lessbinder，moreparaffinwillleadtohigherporosity，permeability。In

8、addition，therateofdrugreleaseofporous13一TCPceramicsdrugcarrierinvitroarealsomeasuredTheresultprovednotonlytheporosity，permeabilityofdrugcarrierbutalsothesolutionofmedicinehaveeffectonrateofdrugreleaseHigherporosity，perme