芳香脲類化合物的合成及其在醇中穩(wěn)定性研究.pdf

1、錄^^iAbstractii第一章前言1i.i脲的發(fā)現(xiàn)及發(fā)展11.2脲在醇中的不穩(wěn)定性3第二章脲類化合物的合成方法72.1以CO或C02為羰基源將兩分子胺直接連接72.2基丁異氰酸酯為中間體的羰基源82.3其它羰基衍生物9第三章芳香脲類化合物的合成113.1弓丨1113.2芳香脲類化合物的合成113.2.1化合物3ao的合成123.2.2化合物3pt的合成153.2.3化合物4fg的合成163.2.4化合物5ac5e5g5k的合成163

2、.2.5化合物6fg的合成183.2.6化合物7g8g的合成方法183.319第四章芳香脲類化合物在醇中穩(wěn)定性研究204.1目標(biāo)化合物醇解速率比較方法204.2芳香脲類化合物的醇解實(shí)驗(yàn)224.3芳香脲類化合物在醇中穩(wěn)定性小結(jié)27第五章實(shí)驗(yàn)部分285.1儀器與試劑285.2實(shí)驗(yàn)部分2843附錄NMRData52$if71復(fù)口.大學(xué)碩士學(xué)位論文abstractAbstractInthisthesisphenylchlofmatewascho

3、senasthecarbonylsource.Severalseriesofaromaticureacompoundsweresynthesizedundermildconditionsusingthisreagent.Thestabilityoftheseseriesofaromaticureacompoundsinalcoholsolventswasstudied.Allthestabilityresultsaresummarize

4、delabated.Dataobtainedfromthisthesiswkwillbeusefulfpeopletouseinthedevelopmentofureacontainingdrugsinthesynthesispurification.Thesynthesisidentificationwkofthesearomaticureacompoundswerecompletedinthisthesis.Agoodroutewa

5、sdevelopedtheprocessparameterswereasfellows:aromaticamineasthesubstrateinTHFDMF，phenylchlofmatewasaddedat05Ctofmactivatedintermediatetheintermediatewasreactedthenwiththeotheraminecomponentinthepresenceofdiisopropylethyla

6、minetoobtainthedesiredaromaticurea.Highconversionwasobtainedundermildconditions.Twopartsoftheureasdesignedarearomaticaminewithelectronwithdrawinggroupselectrondonatinggroupsaliphaticamineofethylpiperazinediethylamineammo

7、niapiperidinempholine.Thirtytwosymmetricalunsymmetricalaromaticureascanbeobtainedintwosimplestepsandtheirstructureswerecharacterized.Thestabilityofthesearomaticureacompoundsinalcoholsolventswasstudied.Researchresultsindi

8、catedthataromaticureacompoundswerenotstableinhightemperature.Nucleophilicsubstitutionoftheureasbythealcoholfmscarbamates.Inaspecialcaseisoamylalcoholwasusedasthesolventanaccelerationexperimentwascarriedouttostudythestabi

9、lityofthefinalproducts.TheratioRofthereactionproductsrawmaterialsindifferenttimesystemswasusedtoreflectitsrateofalcoholysistheresultsshowthatitssubstitutionrateisrelatedwithtemperaturethereactiontimethehigherthetemperatu

10、rethefasterthereplaceratewiththelongerreactiontimesubstituteswillalsoincrease.Aromaticureacompoundswithelectrondonatinggroupsubstitutedaromaticamineshavehighstabilityinthealcoholonthecontrarythosewithelectronwithdrawings

11、ubstituentshavelowstability.Stabilitystudiesofunsymmetricalureacompoundsindicatedthatwhenonesideoftheureabridgeconnectswithanaromaticaminetheothersideconnectswithanaliphaticaminetheureapartofthearomaticsidewasmestablebec