厄洛替尼衍生物的合成與活性研究.pdf

1、分類號UDC密級公玨Z囂廬夕擎碩士研究生學位論文厄洛替尼衍生物的合成與活性研究申請人：學號：培養(yǎng)單位：學科專業(yè)：研究方向：指導教師：完成日期：王雪微2121186化學化工與材料學院有機化學藥物合成化學張華副教授2015年3月20日黑龍江大學碩士學位論文AbstractErlotinibisusedfortreatingthenonsmallcelllungcancer(NSCLC)thatafterfailureofchemothera

2、pyinclinical，andthemechanismforselectivelyblockingtheepidermalgrowthfactorreceptor(EGFR)tyrosinekinaseandautophosphorylationHoweverwitherlotinibwidelyusedinclinicalappeared，adversereactionsanddrugresistanceappearedinsucc

3、essionwhichduetosecondarymutationsinthegene，SOurgentneedformoredrugwhichhavebetterclinicalanticancereffectInthiswork，severalErlotinibderivativesweredesignedandsynthesizedbyetherification，nitrification，reduction，cyclizati

4、on，chlorinated，substitution，using34一DihydroxybenzoicacidethylesterasstartingmaterialsThestructuresofterminationalcompoundsweredeterminedby1HNMR，CNMR，IRandHRMSTheantitumoractivitiesoftheseErlotinibderivativeswereevaluated

5、byanMTTassayTheresultsrevealthatsomeofthetitlecompoundsexhibitpotentantiproliferativeactivitiesagainstselectedtumorcellsAmongthesecompoundsE5，E一6，E一8，E一9，E10，E一15andE一19againstA549wereclosesttoErlotinibInthispaper，prelim

6、inaryfluorescencespectratestoftheseErlotinibderivativesweremeasured，wefoundthatemissionwavelengthsofmostofthesederivativesareinthevisibleregion，therearesomepotentialapplicationvalueThreenewcoordinationpolymers13havebeens

7、ynthesizedbyreactionsoftheN(5Amino一2methylphenyl)4(3pyridyl)一2pyrimidineamine(AMPPA)withtheCd(N03)2“4H20WiththeintroductionofthebuildingblocksofH2ipaandH3btcfeaturing1Dchain，2Dlayerand3DnetworkInaddition，theCd(II)ioneffe