SiO-,2-的仿生合成及在藥物控制釋放中的應用.pdf

1、湖北大學碩士學位論文SiO的仿生合成及在藥物控制釋放中的應用姓名：柴仕淦申請學位級別：碩士專業(yè)：高分子化學與物理指導教師：袁建軍程時遠20090501AbstractCationicfunctionalmicrogelPoly(St—CODMC)wassynthesizedbysoap—freeemulsionpolymerizationwithstyrene(St)andmethacryloyloxyethyltrimethylamm

2、oniumchloride(DMC)Andthen，withthismicrogelastemplateandTMOSassilicasource，hybridnanoparticlesPoly(StCO—DMC)／Si02WasbiomimeticmineralizedattheneutralconditionsThepolymerinhybridparticlesWasremovedbytetrahydrofuran(THF)FTI

3、RanalysisconfirmedsilicadepositionhadtakenplaceandTEManalysisprovedthesilicaWasdepositedmainlyonthesurfaceofmicrogelInaddition，wecancontrolthethicknessofsilicasimplybyadjustingtemperatureorotherconditionsFurtherlywesynth

4、esizedcationicfunctionaltemperaturesensitivemicrogelofPoly(NIPAMCODMClbysoap—freeemulsionpolymerizationwithNisopropylacrylamide(NIPAM)andmethacryloyloxyethyltrimethylammoniumchloride(DMC)TEMstudyindicatedthattheparticles

5、izeofmicrogelWasabout200nrnwithsphericalshapeDLSand1HNMRstudyconfirmedthattheLowerCriticalSolutionTemperature(LCST)ofmicrogelWasabout34℃Then，wedepositedsilicaonthismicrogelwithTMOSassilicasourceatneutralconditionsFTIR，TE

6、M，1HNMRandTGAanalysisindicatedthatSi02depositionhadtakenplaceAndEDXhadprovedthatSi02depositedmainlyontheshellofhybridnanoparticlesFurthermore，asthevolumeofTMOSformineralizationincreased，thesilicathicknessofhybridnanopart

7、iclesincreasedWhenthemineralizationtemperatureishigherthantheLCSTofmicrogel，theobviousabnormalstructurehasformedFinallywehavestudiedthedrugcontrolreleaseusingthesehybridnanoparticleswithaspirinandibuprofen(IBU)asmodeldru

8、gTheresultsindicatedthatthereleaserateofhybridnanoparticlesWasslowerthanthemicrogels，andthereleaserateofhybridnanoparticlesdecreasedasthesilicathicknessoftheparticlesincreasedInaddition，astheNIPAMtemplateistemperaturesen