不同手術(shù)方式對圍手術(shù)期肺癌患者NK、CD3+、CD4+細胞的影響.pdf

1、分類號：R655.3 密級：不保密UDC UDC：612.8 學校代碼：11065碩 士 學 位 論 文不同手術(shù)方式對圍手術(shù)期肺癌患者 不同手術(shù)方式對圍手術(shù)期肺癌患者 NK NK、CD3+ CD3+、CD4+ CD4+細胞的影響 細胞的影響盧 恒 孝 盧 恒 孝指 導 教 師 金 利 新 副教授學科專業(yè)名稱 人體解剖與組織學論文答辯日期 2016 年 4 月 6 日Effects of Different Surgical Approa

2、ches on Perioperative NK, CD3 +,CD4 + cells in Lung CancerAbstractObjective To study the effect of perioperative cellular immune function in lung cancerby video assisted thoracoscope surgery (VATS) and traditional thorac

3、ic surgery (TTS）.Methods 80 cases of patients withⅠ,Ⅱstage of non-small cell lung cancer wererandomly choosed as the subjects of the experiment which were ready to accept thesurgical treatment in the department of thorac

4、ic surgery in Weifang People's hospitalduring 20 December 2014 to 20 June 2015. They were randomly divided into TTSgroup(n=40) and VATS group(n=40). Perioperative cellular immune indexes weredetermined at preoperativ

5、e 24h, postoperative 24 h, postoperative 72 h and postoperative1 week. Data were analyzed by using the SPSS17.0 statistical software.Results In TTS group, the data of NK, CD3 +, CD4 + cells was significantly differentbet

6、ween postoperative 24 h and preoperative 24 h （t=4.30～8.21,p＜0.05） . Also the dataof CD3 cells （t=2.08～2.66， p＜0.05） and CD4 cells （t=2.82～3.00,p＜0.01） wassignificantly different between postoperative 72 h and preoperati

7、ve 24 h. In VATSgroup,the data of NK cells was not significantly different （t=0.50～0.98,p＞0.05）, butthe data of CD3 + and CD4 + cells was significantly different（t=3.22～5.35，p＜0.01）,between postoperative 24 h and preoper

8、ative 24 h. The data of CD3 + and CD4 + cellswas not significantly different between （t=0.46～0.63， p＞0.05） postoperative 72 h andpreoperative 24 h.Conclusion The cellular immune function of the patients with lung cancer