Increase of TRPC 3 expression in left atria of Spontaneous hypertensive rats.pdf

1、Objective: To investigate TRPC 3 expression in left atria of spontaneous hypertensive rats.
　　 Method: 6 WKY rats were used as control group, 24 spontaneoushypertensive rats aged 16 weeks were divided in 4 groups, a

2、group ofspontaneous hypertensive rats, a group which received ramipril 5mg/kg/d,a group which received valsartan 30mg/kg/d and a group which receive damlodipine Smg/kg/d, each for duration of4 weeks. Caudal systolic bloo

3、d pressure and body weight were recorded each day. Expression ofTRPC3 was assessed with RT-PCR, The data are presented as the mean+SD andcompared using paired samples T-test. Significance is determined at thep<0.05 level

4、.
　　 Result and conclusion: (1). Significant increase of TRPC 3expression of atria was highly related with increase of blood pressure(209.8717±0.99292 vs 0, p-value< 0.05). (2). Ramipril, valsartan and amlodipine (18

5、5.3983±12.91843, 134.2433±12.91843, 178.455±10.16149vs 209.8717±0.99292, p-value<0.05) showed to attenuate the density of TRPC 3 expression related to lowering blood pressure compare to SHR group. (3). TRPC 6 wasn't expr